Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Nov 13;62(11):e0102224.
doi: 10.1128/jcm.01022-24. Epub 2024 Oct 9.

Clinical performance evaluation of the BioFire Joint Infection Panel

Rose A Lee  1
Affiliations
Comment

Clinical performance evaluation of the BioFire Joint Infection Panel

Rose A Lee. J Clin Microbiol. .

Abstract

The BioFire Joint Infection (JI) Panel offers a significant advancement in the rapid diagnosis of joint infections by facilitating the simultaneous detection of multiple bacterial and fungal pathogens, as well as resistance markers, directly from synovial fluid samples. An article published in the Journal of Clinical Microbiology by Moran et al. (J Clin Microbiol 62:e00182-24, 2024, https://doi.org/10.1128/jcm.00182-24) presents both prospective and retrospective analyses of the panel's real-world clinical application. The study highlights the panel's benefits, such as its rapid turnaround time and ability to identify challenging pathogens, while also discussing its limitations, particularly in detecting certain off-panel organisms.

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Comment on

References

    1. Moran A, Arellano J, Bregman K, McElvania E. 2024. Evaluation of a BioFire multiplex PCR panel for detection of joint infections using retrospective and prospectively collected specimens. J Clin Microbiol 62:e0018224. doi: 10.1128/jcm.00182-24 - DOI - PMC - PubMed
    1. Esteban J, Salar-Vidal L, Schmitt BH, Waggoner A, Laurent F, Abad L, Bauer TW, Mazariegos I, Balada-Llasat J-M, Horn J, et al. 2023. Multicenter evaluation of the BIOFIRE Joint Infection Panel for the detection of bacteria, yeast, and AMR genes in synovial fluid samples. J Clin Microbiol 61:e0035723. doi: 10.1128/jcm.00357-23 - DOI - PMC - PubMed
    1. Berinson B, Spenke L, Krivec L, Tanida K, Both A, Keller J, Rolvien T, Christner M, Lütgehetmann M, Aepfelbacher M, Klatte TO, Rohde H. 2023. Performance and hypothetical impact on joint infection management of the BioFire joint infection panel: a retrospective analysis. J Clin Microbiol 61:e0059223. doi: 10.1128/jcm.00592-23 - DOI - PMC - PubMed
    1. Azad MA, Wolf MJ, Strasburg AP, Daniels ML, Starkey JC, Donadio AD, Abdel MP, Greenwood-Quaintance KE, Patel R. 2022. Comparison of the BioFire joint infection panel to 16S ribosomal RNA gene-based targeted metagenomic sequencing for testing synovial fluid from patients with knee arthroplasty failure. J Clin Microbiol 60:e0112622. doi: 10.1128/jcm.01126-22 - DOI - PMC - PubMed
    1. Hoffman T, Kriger O, Cohen S, Gefen-Halevi S, Yahav D, Amit S. 2023. Real-life experience and diagnostic utility of the BioFire joint infection PCR panel in bone and joint infections: analysis of a prospective validation study. Infect Dis Ther 12:1437–1443. doi: 10.1007/s40121-023-00809-x - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources