Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study
- PMID: 39382795
- DOI: 10.1007/s11604-024-01671-8
Performance of iodine quantification through high-pitch dual-source photon-counting CT: a phantom study
Abstract
Purpose: To investigate the feasibility and accuracy of iodine quantification using PCD-CT in standard-pitch and high-pitch scanning at different scan parameters in a phantom model.
Materials and methods: Four inserts with known iodine concentrations (2, 5, 10, and 15 mg/mL) were placed in the removable CT phantom and scanned using high-pitch (3.2) and standard-pitch (0.8) modes on PCD-CT. Two tube voltages (120 and 140 kVp) and four radiation doses (1, 3, 5, and 10 mGy) were alternated. Each scan setting was repeated three times. Mean iodine concentration for each insert across three consecutive slices was recorded. Percentage absolute bias (PAB) was assessed for iodine quantification.
Results: A total of 96 acquisitions were conducted. In small phantom, the average for PAB was 2.96% (range: 1.75% ~ 4.56%) and 1.67% (range: 1.00% ~ 3.42%) for high-pitch and standard-pitch acquisitions, respectively. In large phantom, it was 3.72% (range: 1.75% ~ 5.97%) and 2.94% (range: 1.75% ~ 4.70%). Linear regression analysis revealed that only phantom size significantly influenced (P < 0.001) the accuracy of iodine quantification.
Conclusion: The high-pitch scan mode in PCD-CT can be used to quantify iodine density with similar accuracy compared with standard pitch.
Keywords: Dual-source photon-counting detector CT; High-pitch scan; Iodine quantification; Phantom study.
© 2024. The Author(s) under exclusive licence to Japan Radiological Society.
Conflict of interest statement
Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. The authors have no competing interests to declare that are relevant to the content of this article. Ethical approval: This is a phantom study. The Research Ethics Committee has confirmed that no ethical approval is required.
References
-
- Beck S, Jahn L, Deniffel D, Riederer I, Sauter A, Makowski MR, et al. Iodine images in dual energy CT: a monocentric study benchmarking quantitative iodine concentration values of the healthy liver. PLoS ONE. 2022;17(7): e0270805. https://doi.org/10.1371/journal.pone.0270805 . - DOI - PubMed - PMC
-
- Gao W, Zhang Y, Dou Y, Zhao L, Wu H, Yang Z, et al. Association between extramural vascular invasion and iodine quantification using dual-energy computed tomography of rectal cancer: a preliminary study. Eur J Radiol. 2023;158: 110618. https://doi.org/10.1016/j.ejrad.2022.110618 . - DOI - PubMed
-
- Achenbach S, Marwan M, Schepis T, Pflederer T, Bruder H, Allmendinger T, et al. High-pitch spiral acquisition: a new scan mode for coronary CT angiography. J Cardiovasc Comput Tomogr. 2009;3(2):117–21. https://doi.org/10.1016/j.jcct.2009.02.008 . - DOI - PubMed
-
- Morsbach F, Gordic S, Desbiolles L, Husarik D, Frauenfelder T, Schmidt B, et al. Performance of turbo high-pitch dual-source CT for coronary CT angiography: first ex vivo and patient experience. Eur Radiol. 2014;24(8):1889–95. https://doi.org/10.1007/s00330-014-3209-7 . - DOI - PubMed
-
- Flohr TG, Leng S, Yu L, Aiimendinger T, Bruder H, Petersilka M, et al. Dual-source spiral CT with pitch up to 3.2 and 75 ms temporal resolution: image reconstruction and assessment of image quality. Med Phys. 2009;36(12):5641–53. https://doi.org/10.1118/1.3259739 . - DOI - PubMed