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Comment
. 2024 Oct 8;57(10):2263-2265.
doi: 10.1016/j.immuni.2024.09.008.

Superficial ice and deep blaze: A defense strategy of the skin

Zhuoqiong Qiu  1 , Wei Li  2
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Superficial ice and deep blaze: A defense strategy of the skin

Zhuoqiong Qiu et al. Immunity. .

Abstract

It's crucial for skin to establish efficient defense strategies. Liu et al. reveal that the transcription factor ZNF750 recruits the histone demethylase KDM1A to silence pattern recognition receptors in the outer epidermis, making their expression limited to deeper, undifferentiated keratinocytes to address threats penetrating the skin.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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