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Review
. 2024 Oct 9;44(41):e1295242024.
doi: 10.1523/JNEUROSCI.1295-24.2024.

Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?

Joia K Capocchi  1 , Claudia Figueroa-Romero  2 , Sage J B Dunham  1 , Gina Faraci  1 , Jason A Rothman  1   3 , Katrine L Whiteson  1 , Dong-Oh Seo  4 , David M Holtzman  4 , Stefanie Grabrucker  5 , Yvonne M Nolan  5   6 , Rima Kaddurah-Daouk  7 , David A Jett  8
Affiliations
Review

Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?

Joia K Capocchi et al. J Neurosci. .

Abstract

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

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Conflict of interest statement

The authors declare no competing financial interests. R.K.-D. is an inventor on key patents in the metabolomics field and holds equity in Metabolon and Chymia.

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