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. 2024 Oct 9;24(1):2757.
doi: 10.1186/s12889-024-20214-4.

Insulin resistance and sarcopenia: a prognostic longitudinal link to stroke risk in middle-aged and elderly Chinese population

Canhui Guo #  1   2 , Ling He #  2 , Yansong Tu  3 , Chunyan Xu  1   2 , Caifeng Liao  1   2 , Hurong Lai  1   2 , Chuyang Lin  2 , Huaijun Tu  4   5
Affiliations

Insulin resistance and sarcopenia: a prognostic longitudinal link to stroke risk in middle-aged and elderly Chinese population

Canhui Guo et al. BMC Public Health. .

Abstract

Background: Stroke is the leading cause of death in middle-aged and elderly people in China. Insulin resistance (IR) and sarcopenia are both closely associated with metabolic diseases. However, the relationship between these two indicators and stroke has not been fully investigated. The aim of this study was to investigate the relationship between IR and sarcopenia and the risk of new-onset stroke.

Methods: Using longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, Cox proportional hazards models were used to determine the association between IR surrogate indicators and sarcopenia status with stroke incidence.

Results: In the present study, during a median 7 years of follow-up, we included 7009 middle-aged and elderly residents, of whom 515 presented with stroke incidence. After adjustment for potential confounders, both baseline IR surrogates and sarcopenia independently predicted stroke risk. In addition, co-morbidities had a higher risk of stroke than other groups. The positive association between TyG-WC and sarcopenia on stroke risk was particularly significant [HR (95% CI): 2.03 (1.52, 2.70)]. In subgroups of different ages and sexes, the combination of IR and sarcopenia is associated with the highest risk of stroke.

Conclusions: We found that IR and sarcopenia synergistically increase the incidence of stroke in older adults. This finding provides new perspectives for stroke detection and intervention and highlights the importance of early detection and management of IR and sarcopenia in older adults.

Keywords: China health and retirement longitudinal study; Insulin resistance; Sarcopenia; Stroke.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram for participants included in the study. China Health and Retirement Longitudinal Study, CHARLS
Fig. 2
Fig. 2
Subgroup analysis of IR surrogate indicators and sarcopenia status with stroke risk. Hazard Ratio (HR) were adjusted for age, sex, systolic, diastolic, smoking, drinking, hypertension, diabetes, heart disease, dyslipidemia, hypertension medications, diabetes medications and dyslipidemia medications. Body mass index, BMI. Waist circumference, WC. The ratio of waistline to height, WHtR. Triglyceride glucose, TyG. The metabolic score for insulin resistance, METS-IR
See this image and copyright information in PMC

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