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Review
. 2024 Sep 25:12:1466644.
doi: 10.3389/fbioe.2024.1466644. eCollection 2024.

Saccharomyces cerevisiae for lignocellulosic ethanol production: a look at key attributes and genome shuffling

Kindu Nibret Tsegaye  1   2 , Marew Alemnew  2 , Nega Berhane  2
Affiliations
Review

Saccharomyces cerevisiae for lignocellulosic ethanol production: a look at key attributes and genome shuffling

Kindu Nibret Tsegaye et al. Front Bioeng Biotechnol. .

Abstract

These days, bioethanol research is looking at using non-edible plant materials, called lignocellulosic feedstocks, because they are cheap, plentiful, and renewable. However, these materials are complex and require pretreatment to release fermentable sugars. Saccharomyces cerevisiae, the industrial workhorse for bioethanol production, thrives in sugary environments and can handle high levels of ethanol. However, during lignocellulose fermentation, S. cerevisiae faces challenges like high sugar and ethanol concentrations, elevated temperatures, and even some toxic substances present in the pretreated feedstocks. Also, S. cerevisiae struggles to efficiently convert all the sugars (hexose and pentose) present in lignocellulosic hydrolysates. That's why scientists are exploring the natural variations within Saccharomyces strains and even figuring out ways to improve them. This review highlights why Saccharomyces cerevisiae remains a crucial player for large-scale bioethanol production from lignocellulose and discusses the potential of genome shuffling to create even more efficient yeast strains.

Keywords: Saccharomyces cerevisiae; bioethanol; genome shuffling; lignocellulose; strain improvement.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Comparative bioethanol production by parent and shuffled S. cerevisiae strains.
See this image and copyright information in PMC

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