Prophylactic corticosteroids on postoperative neurocognitive dysfunction and Dexamethasone for Cardiac Surgery (DECS) trial

Thomas H Ottens^{1

2}, Jan M Dieleman^{3

4}, Anne-Mette C Sauer⁵, Diederik Van Dijk²

Affiliations

¹ Department of Intensive Care Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
² Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
³ Department of Anaesthesia, Westmead Hospital, Westmead NSW, Australia.
⁴ Department of Anaesthesiology, Translational Health Research Institute, Western Sydney University School of Medicine, Westmead, NSW, Australia.
⁵ Department of Intensive Care Medicine, Antonius Ziekenhuis, Sneek.

Thomas H Ottens et al. Indian J Anaesth. 2024 Sep.

. 2024 Sep;68(9):841.

doi: 10.4103/ija.ija_639_24. Epub 2024 Aug 16.

Thomas H Ottens^{1

2}, Jan M Dieleman^{3

4}, Anne-Mette C Sauer⁵, Diederik Van Dijk²

¹ Department of Intensive Care Medicine, Haga Teaching Hospital, The Hague, The Netherlands.
² Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
³ Department of Anaesthesia, Westmead Hospital, Westmead NSW, Australia.
⁴ Department of Anaesthesiology, Translational Health Research Institute, Western Sydney University School of Medicine, Westmead, NSW, Australia.
⁵ Department of Intensive Care Medicine, Antonius Ziekenhuis, Sneek.

No abstract available

Conflict of interest statement

There are no conflicts of interest.

1. Singh NP, Makkar JK, Goel N, Karamchandani K, Singh M, Singh PM. Effect of prophylactic corticosteroids on postoperative neurocognitive dysfunction in the adult population: An updated systematic review, meta-analysis, and trial sequential analysis of randomised controlled trials. Indian J Anaesth. 2024;68:517–26. - PMC - PubMed
1. Dieleman JM, Nierich AP, Rosseel PM, Van Der Maaten JM, Hofland J, Diephuis JC, et al. Intraoperative high-dose dexamethasone for cardiac surgery a randomized controlled trial. JAMA. 2012;308:1761–7. - PubMed
1. Ottens TH, Dieleman JM, Sauër A-MC, Peelen LM, Nierich AP, de Groot WJ, et al. Effects of dexamethasone on cognitive decline after cardiac surgery: A randomized clinical trial. Anesthesiology. 2014;121:492–500. - PubMed
1. Sauër A-MC, Slooter AJ, Veldhuijzen DS, van Eijk MM, Devlin JW, van Dijk D. Intraoperative dexamethasone and delirium after cardiac surgery: A randomized clinical trial. Anesth Analg. 2014;119:1046–52. - PubMed