Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;183(12):5313-5319.
doi: 10.1007/s00431-024-05810-1. Epub 2024 Oct 10.

Splanchnic and cerebral oxygenation during cyclic phototherapy in preterm infants with hyperbilirubinemia

Carlo Dani  1   2 , Giulia Remaschi  3 , Federica Rossi  3 , Monica Fusco  3 , Chiara Poggi  3 , Iuri Corsini  3 , Simone Pratesi  4   3
Affiliations

Splanchnic and cerebral oxygenation during cyclic phototherapy in preterm infants with hyperbilirubinemia

Carlo Dani et al. Eur J Pediatr. 2024 Dec.

Abstract

Cyclic phototherapy (cPT) can achieve a reduction in total serum bilirubin comparable to that achieved with standard continuous PT in preterm infants. Our aim was to assess the effect of cPT on splanchnic (rSO2S) and cerebral (rSO2C) oxygenation measured by near-infrared spectroscopy (NIRS). We prospectively studied 16 infants with a gestational age of 25-34 weeks with hyperbilirubinemia requiring PT. Splanchnic regional oxygenation (rSO2S), oxygen extraction fraction (FOES), and cerebro-splanchnic oxygenation ratio (CSOR) were recorded before, during, and after cPT discontinuation. We found that rSO2S, FOES, and CSOR did not change during the study period. The overall duration of single or multiple courses of PT was 6.5 (6.0-13.5) h, but by cycling PT, the actual exposure was 3.0 (1.5-4.9) h. Twelve patients (75%) required 15 min/h cPT, and four (25%) required prolonging cPT to 30 min/h. None of the patients developed enteral feeding intolerance. Conclusions: cPT treatment of hyperbilirubinemia in preterm infants does not affect splanchnic oxygenation or intestinal oxygen blood extraction, likely due to the short exposure to PT light, and it could contribute to decreasing the risk of feeding intolerance.

Keywords: Cyclic phototherapy; Feeding intolerance; Near-infrared spectroscopy; Splanchnic oxygenation.

PubMed Disclaimer

Conflict of interest statement

CD received honoraria from Chiesi Farmaceutici Spa, Vyaire Medical Inc., Sanofi Italia, and GEPA Srl for scientific consultancies. The remaining authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Changes of a splanchnic oxygenation (rSO2S), b cerebral oxygenation (rSO2C), c cerebro-splanchnic oxygenation ratio (CSOR), d splanchnic fractional oxygen extraction (FOES), and e cerebral fractional oxygen extraction (FOES) at the different data points of the study. Mean ± (SD)
See this image and copyright information in PMC

References

    1. Le Pichon JB, Riordan SM, Watchko J, Shapiro SM (2017) The neurological sequelae of neonatal hyperbilirubinemia: definitions, diagnosis and treatment of the kernicterus spectrum disorders (KSDs). Curr Pediatr Rev 13:199–209 - PubMed
    1. Maisels MJ, Watchko JF, Bhutani VK, Stevenson DK (2012) An approach to the management of hyperbilirubinemia in the preterm infant less than 35 weeks of gestation. J Perinatol 32:660–664 - PubMed
    1. Morioka I, Nakamura H, Koda T, Yokota T, Okada H, Katayama Y et al (2015) Current incidence of clinical kernicterus in preterm infants in Japan. Pediatr Int 57:494–497 - PubMed
    1. Romagnoli C, Barone G, Pratesi S, Raimondi F, Capasso L, Zecca E et al (2014) Italian guidelines for management and treatment of hyperbilirubinaemia of newborn infants ≥ 35 weeks’ gestational age. Ital J Pediatr 31(40):11 - PMC - PubMed
    1. Morioka I (2018) Hyperbilirubinemia in preterm infants in Japan: new treatment criteria. Pediatr Int 60:684–690 - PubMed

LinkOut - more resources