Unwrapping stemness to revive T cells

Affiliations

Comment

Carlson Tsui et al. Science. 2024.

. 2024 Oct 11;386(6718):148-149.

doi: 10.1126/science.ads6217. Epub 2024 Oct 10.

¹ Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.

Abstract

Targeting epigenetic regulators prevents T cell exhaustion.

Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.
Kang TG, Lan X, Mi T, Chen H, Alli S, Lim SE, Bhatara S, Vasandan AB, Ward G, Bentivegna S, Jang J, Spatz ML, Han JH, Schlotmann BC, Jespersen JS, Derenzo C, Vogel P, Yu J, Baylin S, Jones P, O'Connell C, Grønbæk K, Youngblood B, Zebley CC. Kang TG, et al. Science. 2024 Oct 11;386(6718):eadl4492. doi: 10.1126/science.adl4492. Epub 2024 Oct 11. Science. 2024. PMID: 39388542 Free PMC article.