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. 2024 Oct 9;32(10):1639-1641.
doi: 10.1016/j.chom.2024.09.006.

Bacteria renew an OLD protein to cleave host tRNAs and block phage translation

Kyle D Gibbs  1 , Michele LeRoux  2
Affiliations

Bacteria renew an OLD protein to cleave host tRNAs and block phage translation

Kyle D Gibbs et al. Cell Host Microbe. .

Abstract

Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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