How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
- PMID: 39389615
- DOI: 10.1183/13993003.01573-2024
How many functioning ciliated airway epithelial cells are necessary for effective mucociliary clearance?
Conflict of interest statement
Conflict of interest: R.M. Urbantat is participant of the Berlin Institute of Health (BIH) – Charité Junior Clinician Scientist Program funded by the Charité – Universitätsmedizin Berlin, the BIH and the Alliance4Rare. M.A. Mall reports grants from the German Research Foundation (DFG), the German Ministry of Education and Research (BMBF), German Innovation Fund, Vertex Pharmaceuticals and Boehringer Ingelheim, fees for advisory board participation or consulting from Abbvie, Boehringer Ingelheim, Enterprise Therapeutics, Kither Biotech, Pari, Prieris, Recode, Splisense and Vertex Pharmaceuticals, lecture honoraria from Vertex Pharmaceuticals, and travel support from Boehringer Ingelheim and Vertex Pharmaceuticals.
Comment on
-
A range of 30-62% of functioning multiciliated airway cells is sufficient to maintain ciliary airway clearance.Eur Respir J. 2024 Oct 10;64(4):2301441. doi: 10.1183/13993003.01441-2023. Print 2024 Oct. Eur Respir J. 2024. PMID: 38991708 Free PMC article.
Similar articles
-
Modulation of Ion Transport to Restore Airway Hydration in Cystic Fibrosis.Genes (Basel). 2021 Mar 22;12(3):453. doi: 10.3390/genes12030453. Genes (Basel). 2021. PMID: 33810137 Free PMC article. Review.
-
Differentiation of human bronchial epithelial cells: role of hydrocortisone in development of ion transport pathways involved in mucociliary clearance.Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C225-36. doi: 10.1152/ajpcell.00073.2016. Epub 2016 Jun 15. Am J Physiol Cell Physiol. 2016. PMID: 27306366 Free PMC article.
-
TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis.Am J Respir Crit Care Med. 2020 Apr 15;201(8):946-954. doi: 10.1164/rccm.201908-1641OC. Am J Respir Crit Care Med. 2020. PMID: 31898911 Free PMC article.
-
The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke.Am J Respir Cell Mol Biol. 2017 Jan;56(1):99-108. doi: 10.1165/rcmb.2016-0226OC. Am J Respir Cell Mol Biol. 2017. PMID: 27585394 Free PMC article.
-
INSIGHTS INTO THE ORIGINS OF CYSTIC FIBROSIS LUNG DISEASE.Trans Am Clin Climatol Assoc. 2024;134:29-36. Trans Am Clin Climatol Assoc. 2024. PMID: 39135587 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources