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Review
. 2024 Nov;44(4):751-763.
doi: 10.1016/j.iac.2024.07.008. Epub 2024 Aug 22.

Biologics in Asthma: Emerging Biologics

Brinda Desai  1 , Muhammad Adrish  2 , Arjun Mohan  3 , Njira L Lugogo  4
Affiliations
Review

Biologics in Asthma: Emerging Biologics

Brinda Desai et al. Immunol Allergy Clin North Am. 2024 Nov.

Abstract

Advances in our understanding of asthma pathophysiology have led to the advent of multiple targeted asthma therapies such as biologics. However, partial response to biologics occurs, indicating residual disease activity in some patients. Hence, there exists a need for new therapies that focus on novel pathways, alongside perhaps evaluation of combination biologic therapies and modulators of downstream cytokine activation. Therefore, although our current focus is on biologics; it is critical to take a more holistic approach including consideration for nonbiologic therapies that have the potential to significantly advance asthma care.

Keywords: Asthma; Biologics; Inflammation; Type 2 asthma.

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Conflict of interest statement

Disclosure N.L. Lugogo received consulting fees from Amgen, AstraZeneca, Avillion, Genentech, GSK, Nioxx, Novartis, Regeneron, Sanofi, and Teva; honoraria for nonspeakers bureau presentations from GSK, TEVA, and Astra Zeneca, United Kingdom; and travel support from AstraZeneca, Sanofi, Teva, Israel, Regeneron, and GSK; her institution received research support from Amgen, United States AstraZeneca, Avillion, Bellus, Evidera, Gossamer Bio, Genentech, United States GSK, Janssen, United States Regeneron, United States Sanofi, United States, Novartis, Switzerland and Teva. She is an honorary faculty member of Observational and Pragmatic Research Institute (OPRI) but does not receive compensation for this role. N.L. Lugogo participated in the draft of the article, provided edits of all versions of the article and provided final approval of the version to be published. I have disclosed all relevant conflict of interests. B. Desai had effort supported by a T32 training grant (T32 grant: NIHT32 AI 007469).

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