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Review
. 2024 Oct;30(10):1355-1366.
doi: 10.1016/j.cardfail.2024.06.017.

Atrial Mechanics, Atrial Cardiomyopathy and Impact of Atrial Interventions

Veraprapas Kittipibul  1 , Michal Laufer-Perl  2 , Kathir Balakumaran  3 , Maria Rosa Costanzo  4 , Thomas H Marwick  5 , Fawaz Alenezi  6 , Rajeev C Mohan  7 , Vinay Thohan  8 , Kunjan Bhatt  9 , Roberto Hodara Friedmann  10 , Frank Smart  11 , Peter M Eckman  12 , Tajinderpal Saraon  13 , Jan Biegus  14 , Christina Paitazoglou  15 , Nadira Hamid  12 , Rohit Amin  16 , Ann Tong  17 , Marat Fudim  18
Affiliations
Review

Atrial Mechanics, Atrial Cardiomyopathy and Impact of Atrial Interventions

Veraprapas Kittipibul et al. J Card Fail. 2024 Oct.

Abstract

Our comprehension of atrial mechanics, atrial cardiomyopathy and their clinical implications across various cardiovascular conditions has advanced significantly. Atrial interventions can have differing effects on atrial mechanics. With the rapid increase in the use of atrial interventions, it is crucial for investigators and clinicians to acknowledge the potential adverse effects of these interventions on atrial mechanics that might not be clinically significant at the time of interventions. Recognizing the preclinical stage of atrial maladaptation might enable early interventions before the development of irreversible atrial remodeling and clinical manifestation. We review normal atrial function and mechanics, and atrial cardiomyopathy in select cardiovascular conditions. We also summarize and discuss the current evidence of the impact of various atrial interventions on atrial function and mechanics.

Keywords: Atrial mechanics; atrial cardiomyopathy; atrial interventions; atrial septal defect; atrial shunting therapy; heart failure.

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Conflict of interest statement

Disclosures ML-P has received speaker honoraria from BI, AstraZeneca, Novartis, Pfizer, Novonordisk, Abbvie, Bayer, Medison, V-wave, and Alleviant and has served as a consultant to BI, Astrazeneca and Bayer, receives research grants from BI, AstraZeneca, Novartis, Pfizer, and Bayer. THM is supported by an Investigator grant (2008129) from the National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia). MR has received research support from Corvia and V-Wave paid to the institution. VT is a consultant for Abbott, Impulse Dynamics and Battelle and participated in speaker's bureaus for Pfizer and Boehringer Ingelheim. KB is on the speaker's bureau for Abbott, Pfizer and Novartis and is a consultant for Abbott. FS has received research grants from Amgen and is a consultant for Abbott. AT has received speaker honoraria from Bristol-Myers Squibb. MF is supported by the NIH (1OT2HL156812-01; 1R01HL171305-01) and Doris Duke and has received consulting fees from Abbott, Ajax, Alio Health, Alleviant, Artha, Audicor, AxonTherapies, Bayer, Bodyguide, Bodyport, Boston Scientific, Broadview, Cadence, Cardioflow, Cardionomics, Coridea, CVRx, Daxor, Deerfield Catalyst, Edwards LifeSciences, Echosens, EKO, Feldschuh Foundation, Fire1, FutureCardia, Galvani, Gradient, Hatteras, HemodynamiQ, Impulse Dynamics, Intershunt, Medtronic, Merck, NIMedical, NovoNordisk, NucleusRx, NXT Biomedical, Orchestra, Pharmacosmos, PreHealth, Presidio, Procyreon, ReCor, Rockley, SCPharma, Shifamed, Splendo, Summacor, SyMap, Verily, Vironix, Viscardia, and Zoll. All other authors have no relevant financial disclosures.

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