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Review
. 2024 Sep 26;28(6):563.
doi: 10.3892/ol.2024.14697. eCollection 2024 Dec.

Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)

Zhao Guo  1 , Haoyan Zhuang  1 , Xuewen Shi  2
Affiliations
Review

Therapeutic efficacy of ferroptosis in the treatment of colorectal cancer (Review)

Zhao Guo et al. Oncol Lett. .

Abstract

Colorectal cancer (CRC) is the third most common malignancy worldwide, and the second leading cause of cancer-associated mortality. The incidence and mortality rates of CRC remain high, posing a significant threat to humans and overall quality of life. Current therapeutic strategies, such as surgery and chemotherapy, are limited due to disease recurrence, chemotherapeutic drug resistance and toxicity. Thus, research is focused on the development of novel treatment approaches. In 2012, ferroptosis was identified as a form of regulated cell death that is iron-dependent and driven by lipid peroxidation. Notably, therapies targeting ferroptosis exhibit potential in the treatment of disease; however, their role in CRC treatment remains controversial. The present study aimed to systematically review the mechanisms and signaling pathways of ferroptosis in CRC, and the specific role within the tumor microenvironment. Moreover, the present study aimed to review the role of ferroptosis in drug resistance, offering novel perspectives for the diagnosis and treatment of CRC.

Keywords: colorectal cancer; drug resistance; ferroptosis; mechanism of action; signaling pathway; tumor microenvironment.

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Conflict of interest statement

All authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Ferroptosis is implicated in a wide range of diseases, including neurological, cardiac, cerebral, spinal cord, gastrointestinal, gynecological and hepatic disorders.
Figure 2.
Figure 2.
Regulatory mechanisms of ferroptosis. SLC7A11, solute carrier family 7 member 11; SLC3A2, solute carrier family 3 Member 2; System Xc-, cystine/glutamate antiporter system; GSH, glutathione; GSSG, oxidized glutathione; GPX4, glutathione peroxidase 4; PUFA, polyunsaturated fatty acid; ACSL4, acyl-CoA synthetase long-chain family member 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; TFR1, transferrin receptor 1; STEAP3, six transmembrane epithelial antigen of the prostate 3; DMT1, divalent metal transporter 1; NCOA4, nuclear receptor coactivator 4; ROS, reactive oxygen species.
Figure 3.
Figure 3.
Fenton reaction.
See this image and copyright information in PMC

References

    1. Favoriti P, Carbone G, Greco M, Pirozzi F, Pirozzi RE, Corcione F. Worldwide burden of colorectal cancer: A review. Updates Surg. 2016;68:7–11. doi: 10.1007/s13304-016-0359-y. - DOI - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K, International Agency for Research on Cancer Monograph Working Group Carcinogenicity of consumption of red and processed meat. Lancet Oncol. 2015;16:1599–1600. doi: 10.1016/S1470-2045(15)00444-1. - DOI - PubMed
    1. Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, et al. Metabolism links bacterial biofilms and colon carcinogenesis. Cell Metab. 2015;21:891–897. doi: 10.1016/j.cmet.2015.04.011. - DOI - PMC - PubMed
    1. Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci USA. 2014;111:18321–18326. doi: 10.1073/pnas.1406199111. - DOI - PMC - PubMed

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