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Case Reports
. 2024 Aug 14:21:25.
doi: 10.25259/Cytojournal_43_2023. eCollection 2024.

Challenge in the cytological interpretation of a not-so-typical breast carcinoma

Femela Muniraj  1 , Sudha Srinivasan  1 , Vijayashree Raghavan  1
Affiliations
Case Reports

Challenge in the cytological interpretation of a not-so-typical breast carcinoma

Femela Muniraj et al. Cytojournal. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:
Microphotographs of the cytology smears (May GrunwaldGiemsa [MGG]): (a and b) (MGG, ×200), Fine-needle aspiration cytology (FNAC) smears showing cells with vacuolated cytoplasm, (c) (MGG, ×200) FNAC smear showing benign ductal epithelial cells with apocrine metaplasia along with the foamy cells, (d and e) (MGG, ×400) Fine-needle aspiration cytology (FNAC) smears showing cells with vacuolated cytoplasm, (f) (MGG, ×1000) Cells with well-defined cytoplasmic borders.
Figure 2:
Figure 2:
Gross and histopathology of the lesion: (a) Gross image of the modified radical mastectomy specimen, (b) Cut section of the tumor, (c) Histological section of the tumor (hematoxylin & eosin [H & E], ×200), and (d) Section showing the cells with apocrine differentiation (H & E, ×400).
Figure 3:
Figure 3:
Immunohistochemistry of the tumor: (a) Estrogen receptor (ER) is negative in tumor cells (ER and Diaminobenzidine [DAB], ×200), (b) Progesterone receptor (PR) is negative in tumor cells (PR and DAB, ×200), (c) Human epidermal growth factor receptor 2 (HER2)/neu shows diffuse, strong membranous positivity (Grade 3+) (HER2 and DAB, ×200), (d) Ki-67 (Proliferation marker) is positive in 46% of cells (Ki-67 and DAB, ×200), (e) Cytokeratin (CK5/6/8/18): Strong cytoplasmic to membranous positivity in >50% of the cells (CK5/6/8/18 and DAB, ×200), and (f) Androgen receptor is positive in the nuclei of cells with apocrine morphology (androgen receptor and DAB, ×200).
Figure 4:
Figure 4:
Algorithm for the cytological approach to cells with vacuolated cytoplasm in breast aspirate. (PAS: periodic acid-schiff, H/O: History of.) Algorithm plotted using Microsoft PowerPoint [Microsoft Office Standard 2016, Version 16.0; Manufacturer: Microsoft Corporation, Origin: Silicon Valley, CA, USA]
See this image and copyright information in PMC

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