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Case Reports
. 2024 Sep 10;16(9):e69083.
doi: 10.7759/cureus.69083. eCollection 2024 Sep.

ROS1-Rearranged Lung Cancer With Extensive Calcification on Computed Tomography: A Case Report

Junya Yoshioka  1 , Kentaro Hizume  1 , Shigeaki Iwatsubo  1 , Kanoko Matsumura  1 , Yasuhiro Funada  1
Affiliations
Case Reports

ROS1-Rearranged Lung Cancer With Extensive Calcification on Computed Tomography: A Case Report

Junya Yoshioka et al. Cureus. .

Abstract

Although calcified lung cancers are occasionally observed, they are quite rare. We report a case of extensively calcified lung adenocarcinoma with ROS1 fusions. A 57-year-old Japanese woman was initially diagnosed with adenocarcinoma based on aspiration cytology of an enlarged left supraclavicular fossa lymph node at the Department of Otorhinolaryngology at our institution. Subsequent chest imaging suggested primary lung cancer, leading to a referral to the Department of Respiratory Medicine. Computed tomography of the chest revealed a nodular shadow in the right S5 lobe and enlarged mediastinal lymph nodes with extensive calcification. A bronchoscopy with transbronchial lung biopsy of the right S5 nodule confirmed the diagnosis of adenocarcinoma. The biopsy specimen was analyzed using the AmoyDx® Pan Lung Cancer PCR Panel, which detected ROS1 fusions.

Keywords: adenocarcinoma; calcification; crizotinib; enutrectinib; lung cancer; ros1.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. CT
(A, B) CT showing a 25 × 14 mm nodular shadow in the right S5 lobe. (C, D) Hilar and mediastinal lymph nodes exhibiting extensive calcification. (E-H) Changes observed after one month of ROS1/MET inhibitor therapy. CT, computed tomography
Figure 2
Figure 2. Pathological histology
Adenocarcinoma with glandular cavity formation (H&E stain, ×20 magnification)
See this image and copyright information in PMC

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