Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 26;10(19):e38497.
doi: 10.1016/j.heliyon.2024.e38497. eCollection 2024 Oct 15.

Exploring nanobioceramics in wound healing as effective and economical alternatives

Hanan Adnan Shaker Al-Naymi  1 , Mastafa H Al-Musawi  2 , Marjan Mirhaj  3 , Hamideh Valizadeh  4 , Arefeh Momeni  5 , Amir Mohammad Danesh Pajooh  6 , Mina Shahriari-Khalaji  7 , Fariborz Sharifianjazi  8   9 , Ketevan Tavamaishvili  10 , Nafise Kazemi  11 , Saeideh Salehi  11 , Ahmadreza Arefpour  11 , Mohamadreza Tavakoli  3
Affiliations
Review

Exploring nanobioceramics in wound healing as effective and economical alternatives

Hanan Adnan Shaker Al-Naymi et al. Heliyon. .

Abstract

Wound healing is a sophisticated process for which various treatment methods have been developed. Bioceramics with the ability to release inorganic ions in biological environments play a crucial role in cellular metabolism and exhibit bactericidal activity, contributing to numerous physiological processes. Their multifaceted roles in biological systems highlight their significance. The release of different metallic ions from bioceramics enables the repair of both hard and soft tissues. These ions may be effective in cell motility, proliferation, differentiation, adhesion, angiogenesis, and antibiosis. Unlike conventional medications, the bioactivity and antibacterial properties of bioceramics are typically not associated with side effects or bacterial resistance. Bioceramics are commonly recognized for their capcity to facilitate the healing of hard tissues due to their exceptional mechanical properties. In this review, we first explore wound treatment and its prevalent methods, and subsequently, we discuss the application of three primary categories of bioceramics-oxide ceramics, silicate-based ceramics, and calcium-phosphate ceramics-in the context of wound treatment. This review introduces bioceramics as a cost-effective and efficient alternative for wound repair. Our aim is to inspire researchers to incorporate bioceramics with other biomaterials to achieve enhanced, economical, expedited, and safer wound healing.

Keywords: Angiogenesis; Antibacterial; Bioceramics; Inorganic ions; Wound treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Four consecutive and overlapping phases of wound healing.
Fig. 2
Fig. 2
illustrates how wound dressing functions as a protective shield, separating the injured tissue from the ambient surroundings.
Fig. 3
Fig. 3
Covering the wound surface with antibacterial agent-loaded dressings prevents the penetration of microorganisms and wound infection.
Fig. 4
Fig. 4
Schematic illustration of ion-mediated functionallities in skin tissue repair.
Fig. 5
Fig. 5
Three main categories of bioceramics and common inorganic ions in their structure.
Fig. 6
Fig. 6
A schematic illustration outlining the contribution of various ions (both doped and non-doped) released from bioactive glasses at different stages of wound healing.
See this image and copyright information in PMC

References

    1. Song Z., Wang J., Tan S., Gao J., Wang L. Conductive biomimetic bilayer fibrous scaffold for skin regeneration. Colloids Surf. A Physicochem. Eng. Asp. 2023;656
    1. Mirhaj M., Varshosaz J., Labbaf S., Emadi R., Seifalian A.M., Sharifianjazi F., Tavakoli M. Mupirocin loaded core-shell pluronic-pectin-keratin nanofibers improve human keratinocytes behavior, angiogenic activity and wound healing. Int. J. Biol. Macromol. 2023 - PubMed
    1. Freeth T., Jones A., Steele J.M., Bitsakis Y. Calendars with olympiad display and eclipse prediction on the antikythera mechanism. Nature. 2008;454:614–617. - PubMed
    1. Pajooh A.M.D., Tavakoli M., Al-Musawi M.H., Karimi A., Salehi E., Nasiri-Harchegani S., Sharifianjazi F., Tavamaishvili K., Mehrjoo M., Najafinezhad A. Biomimetic VEGF-loaded bilayer scaffold fabricated by 3D printing and electrospinning techniques for skin regeneration. Mater. Des. 2024;238
    1. Mirhaj M., Varshosaz J., Labbaf S., Emadi R., Seifalian A.M., Sharifianjazi F. An antibacterial Multi-Layered scaffold fabricated by 3D printing and electrospinning methodologies for skin tissue regeneration. Int. J. Pharm. 2023;645 - PubMed

LinkOut - more resources