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Review
. 2024 Oct;91(10):e23777.
doi: 10.1002/mrd.23777.

Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities

Tessa Lord  1   2 , Jon M Oatley  3
Affiliations
Review

Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities

Tessa Lord et al. Mol Reprod Dev. 2024 Oct.

Abstract

The actions of spermatogenic stem cells (SSCs) provide the foundation for continual spermatogenesis and regeneration of the cognate lineage following cytotoxic insult or transplantation. Several decades of research with rodent models have yielded knowledge about the core biology, morphological features, and molecular profiles of mammalian SSCs. Translation of these discoveries to utilities for human fertility preservation, improving animal agriculture, and wildlife conservation are actively being pursued. Here, we provide overviews of these aspects covering both historical and current states of understanding.

Keywords: mammal; spermatogenesis; spermatogonia; spermatogonial stem cell.

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References

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