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Review
. 2025 Jan;55(1):88-103.
doi: 10.1007/s00247-024-06057-6. Epub 2024 Oct 11.

Intracranial manifestations of central nervous system tuberculosis in children

Claudia Lazarte-Rantes  1 , Mario Sinti-Ycochea  2 , Daniel Guillen-Pinto  3
Affiliations
Review

Intracranial manifestations of central nervous system tuberculosis in children

Claudia Lazarte-Rantes et al. Pediatr Radiol. 2025 Jan.

Abstract

Tuberculosis remains a significant global health challenge, with central nervous system tuberculosis (CNS-TB) posing a substantial threat, accounting for 1-10% of all tuberculosis cases. This article explores the diverse manifestations of CNS-TB in children, with a particular focus on tuberculous meningitis and tuberculomas, as well as their associated complications. Diagnostic imaging, including CT and MRI, plays a crucial role in the early detection of CNS-TB. The article emphasizes the pivotal role of imaging in the diagnosis and management of these manifestations, underscoring the importance of early recognition by healthcare professionals. Ultimately, raising awareness among pediatric radiologists, pediatricians, and pediatric neurologists is crucial for prompt intervention and improved outcomes in cases of CNS-TB.

Keywords: Brain; Central nervous system; Children; Computed tomography; Magnetic resonance imaging; Tuberculoma; Tuberculosis; Tuberculous meningitis.

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Conflict of interest statement

Declarations. Ethics approval: This study was approved by the Institutional Review Board of the Instituto Nacional de Salud del Niño San Borja. Consent to participate and consent for publication: A waiver for consent was granted by the Institutional Review Board of the Instituto Nacional de Salud del Niño San Borja. Conflicts of interest: None.

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References

    1. Muzumdar D, Vedantam R, Chandrashekhar D (2018) Tuberculosis of the central nervous system in children. Childs Nerv Syst 34:1925–1935 - PubMed
    1. version) GtrGWHOLCB-N-SII----e.
    1. Lamb GS, Starke JR (2017) Tuberculosis in infants and children. Microbiol Spectr 5. https://doi.org/10.1128/microbiolspec.TNMI7-0037-2016
    1. Mertiri L, Freiling JT, Desai NK, Kralik SF, Huisman T (2024) Pediatric and adult meningeal, parenchymal, and spinal tuberculosis: a neuroimaging review. J Neuroimaging 34:179–194 - PubMed
    1. Perez-Malagon CD, Barrera-Rodriguez R, Lopez-Gonzalez MA, Alva-Lopez LF (2021) Diagnostic and neurological overview of brain tuberculomas: a review of literature. Cureus 13:e20133 - PubMed - PMC

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