The Arousal Threshold: The "Weakest Link" in Obstructive Sleep Apnea Pathogenesis?

Simon A Joosten^{1

2

3}, Bradley A Edwards^{4

5}, Shane A Landry⁴

Affiliations

¹ Monash Lung, Sleep, Allergy, and Immunity Monash Health Clayton, Victoria, Australia.
² School of Clinical Sciences Monash University Melbourne, Victoria, Australia.
³ Monash Partners - Epworth Clayton, Victoria, Australia.
⁴ Biomedical Discovery Institute Monash University Melbourne, Victoria, Australia.
⁵ School of Psychological Sciences Monash University Melbourne, Victoria, Australia.

Editorial

Simon A Joosten et al. Am J Respir Crit Care Med. 2024.

. 2024 Dec 15;210(12):1396-1397.

doi: 10.1164/rccm.202408-1523ED.

Simon A Joosten^{1

2

3}, Bradley A Edwards^{4

5}, Shane A Landry⁴

¹ Monash Lung, Sleep, Allergy, and Immunity Monash Health Clayton, Victoria, Australia.
² School of Clinical Sciences Monash University Melbourne, Victoria, Australia.
³ Monash Partners - Epworth Clayton, Victoria, Australia.
⁴ Biomedical Discovery Institute Monash University Melbourne, Victoria, Australia.
⁵ School of Psychological Sciences Monash University Melbourne, Victoria, Australia.

No abstract available

Comment on

Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis.
Messineo L, Sands SA, Labarca G. Messineo L, et al. Am J Respir Crit Care Med. 2024 Dec 15;210(12):1461-1474. doi: 10.1164/rccm.202403-0501OC. Am J Respir Crit Care Med. 2024. PMID: 39042859 Free PMC article.

1. Younes M. Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med . 2004;169:623–633. - PubMed
1. Jordan AS, Eckert DJ, Wellman A, Trinder JA, Malhotra A, White DP. Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med . 2011;184:1183–1191. - PMC - PubMed
1. Sands SA, Edwards BA, Terrill PI, Taranto-Montemurro L, Azarbarzin A, Marques M, et al. Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea. Am J Respir Crit Care Med . 2018;197:1187–1197. - PMC - PubMed
1. Messineo L, Sands SA, Labarca G. Hypnotics on obstructive sleep apnea severity and endotypes: a systematic review and meta-analysis. Am J Respir Crit Care Med . 2024;210:1461–1474. - PMC - PubMed
1. Edwards BA, Eckert DJ, McSharry DG, Sands SA, Desai A, Kehlmann G, et al. Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea. Am J Respir Crit Care Med . 2014;190:1293–1300. - PMC - PubMed