IL-12/IL-23 Blockade Reveals Patterns of Asynchronous Inflammation in Pyoderma Gangrenosum

Affiliations

¹ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA.
² Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
³ Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁴ Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁵ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA; Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁶ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: moreauj@ohsu.edu.

Free article

Rashi Yadav et al. J Invest Dermatol. 2025 May.

Free article

. 2025 May;145(5):1209-1212.e3.

doi: 10.1016/j.jid.2024.08.040. Epub 2024 Oct 10.

¹ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA.
² Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
³ Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁴ Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁵ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA; Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.
⁶ Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA; Division of Oncological Sciences, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA. Electronic address: moreauj@ohsu.edu.

No abstract available

Keywords: B cells; Pyoderma gangrenosum; Spatial transcriptomics; Tertiary lymphoid structures; Ustekinumab.

Update of

IL-12/IL23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum.
Yadav R, Vague M, Rettig M, Loo CP, Brown K, Samiea A, Moreau JM, Ortega-Loayza AG. Yadav R, et al. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591387. doi: 10.1101/2024.04.26.591387. bioRxiv. 2024. Update in: J Invest Dermatol. 2025 May;145(5):1209-1212.e3. doi: 10.1016/j.jid.2024.08.040. PMID: 38746177 Free PMC article. Updated. Preprint.