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Review
. 2025 Apr;43(4):738-741.
doi: 10.1016/j.tibtech.2024.09.016. Epub 2024 Oct 10.

Advancements and regulations of biomanufacturing cell-based cartilage repair therapies

Jia Qian Tor  1 , Quang Bach Le  2 , Hariharan Ezhilarasu  1 , Weng Wan Chan  1 , Deepak Choudhury  3
Affiliations
Review

Advancements and regulations of biomanufacturing cell-based cartilage repair therapies

Jia Qian Tor et al. Trends Biotechnol. 2025 Apr.

Abstract

Cell-based therapies for cartilage repair, including autologous chondrocyte implantation and allogeneic stem cell treatments, show great promise but face challenges due to high costs and regulatory hurdles. This review summarizes available and investigational products, focusing on allogeneic therapies and the impact of diverse regulatory landscapes on their clinical translation.

Keywords: ACI; MSC; cartilage repair; cell therapy; clinical trial; regulatory.

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Conflict of interest statement

Declaration of interests None declared by authors.

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