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Multicenter Study
. 2024 Oct 11;24(1):653.
doi: 10.1186/s12887-024-05117-y.

Incidence and predictors of opportunistic infections among HIV-infected children on antiretroviral therapy at public health facilities of Southwest Ethiopia People Regional State, 2023: a multicenter retrospective follow-up study

Nigatu Admasu  1   2 , Mohammed Jihad  3 , Abeje Kebede  3 , Masrie Getnet  3
Affiliations
Multicenter Study

Incidence and predictors of opportunistic infections among HIV-infected children on antiretroviral therapy at public health facilities of Southwest Ethiopia People Regional State, 2023: a multicenter retrospective follow-up study

Nigatu Admasu et al. BMC Pediatr. .

Abstract

Background: Opportunistic infections (OIs) pose a significant threat to children infected with HIV. Despite advancements in antiretroviral therapy (ART), these infections continue to be a public health concern. However, there is limited evidence regarding the incidence and predictors of OIs among HIV-infected children in Ethiopia, particularly in the study area. Therefore, the objective of this study was to assess the incidence and predictors of OIs among HIV-infected children on ART at public health facilities of Southwest Ethiopia People Regional State.

Methods: The study employed an institution-based retrospective cohort design, conducted from July 1, 2018 to July 31, 2023, among HIV-infected children aged less than 15 years. Data were extracted using the national ART intake and follow-up forms. KoboCollect version 2023.2.4 and STATA version 14.0 were used for data collection and analysis, respectively. The Kaplan-Meier survival curve was used to estimate the probability of OI-free survival time. Variables with P-value < 0.25 in the bivariable Cox proportional hazard model were selected as candidates. In multivariable analysis, P-value < 0.05 and adjusted hazard ratio (AHR) with 95% confidence interval (CI) were used to declare statistically significant predictors.

Results: Of the total 409 HIV infected children, 122(29.8%) developed at least one OI, contributing to 954.95 person-years of risk. The overall incidence rate was 12.8 (95% CI: 10.7, 15.2) per 100 person-years. The OI-free survival probability at the end of the follow-up period was 0.277(95% CI: 0.139, 0.434). The commonest OI was pulmonary tuberculosis, 30.33% (95% CI: 22.7, 39.2). Non-disclosing HIV status (AHR: 2.56, 95% CI: 1.42, 4.63), children aged 10-14 years (AHR: 2.34, 95% CI: 1.10, 4.95), no history of prevention of mother-to-child transmission of HIV (AHR: 2.33, 95% CI: 1.48, 3.66), hemoglobin level < 10 mg/dL (AHR: 2.26, 95% CI: 1.37, 3.75), fair or poor adherence to ART (AHR: 1.74, 95% CI: 1.09, 2.79), and having past history of OIs (AHR: 1.61, 95% CI: 1.03, 2.55) were statistically significant predictors of OIs.

Conclusion and recommendations: The incidence of OIs was high in the study area. Hence, health facilities need to regularly monitor hemoglobin, enhance ART adherence, provide OI prophylaxis for at-risk children, reinforce PMTCT programs for early OI detection and management, and encourage timely and age-appropriate HIV status disclosure. Caregivers of HIV-infected children are also required to oversee and assist their children in adhering to the ART.

Keywords: Antiretroviral therapy; Children; Ethiopia; HIV; Opportunistic infections.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Map of study areas, Southwest Ethiopia People Regional State, 2023
Fig. 2
Fig. 2
Goodness of fit test for the cox-proportional hazard regression model
Fig. 3
Fig. 3
Flow diagram showing study population selection among HIV-infected children receiving ART at public health facilities of SWEPRS, 2023
Fig. 4
Fig. 4
The proportion of opportunistic infections identified among HIV-infected children after the initiation of ART at public health facilities of SWERS, 2023 (n = 122)
Fig. 5
Fig. 5
The overall KM curve of opportunistic infection-free survival time of HIV infected children on ART at public health facilities, SWEPRS, 2023
Fig. 6
Fig. 6
KM OIs-free survival time of HIV-infected children on ART among history of PMTCT at public health facilities, SWEPRS, 2023
Fig. 7
Fig. 7
KM OIs-free survival time of HIV-infected children among ART adherence levels at public health facilities, SWEPRS, 2023
Fig. 8
Fig. 8
KM OIs-free survival time of HIV-infected children on ART among those having past history of OIs at public health facilities, SWEPRS, 2023
Fig. 9
Fig. 9
KM OIs-free survival time of HIV-infected children on ART among hemoglobin levels at public health facilities, SWEPRS, 2023
Fig. 10
Fig. 10
KM OIs-free survival time of HIV-infected children on ART among HIV disclosure status at public health facilities, SWEPRS, 2023
Fig. 11
Fig. 11
KM OIs-free survival time of HIV-infected children on ART among age groups at public health facilities of SWEPRS, 2023
See this image and copyright information in PMC

References

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