British Gynaecological Cancer Society and British Menopause Society guidelines: Management of menopausal symptoms following treatment of gynaecological cancer

Alexandra Taylor^{1

2}, Kathryn Clement³, Timothy Hillard⁴, Jenifer Sassarini⁵, Nithya Ratnavelu⁶, Holly Baker-Rand⁷, Rebecca Bowen^{8

9}, Melanie C Davies¹⁰, Katherine Edey¹¹, Andreia Fernandes¹, Sadaf Ghaem-Maghami¹², Nana Gomes¹, Sarah Gray¹³, Eluned Hughes¹⁴, Anna Hudson¹⁵, Ranjit Manchanda^{16

17}, Kristyn Manley¹⁸, Shibani Nicum^{19

20}, Andrew Phillips²¹, Alison Richardson²¹, Jo Morrison^{7

22}

Affiliations

¹ Department of Gynaecology Oncology, The Royal Marsden Hospital NHS Trust, London, UK.
² The Institute of Cancer Research, London, UK.
³ Department of Gynaecology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
⁴ Department of Gynaecology, University Hospitals Dorset NHS Foundation Trust, Poole, UK.
⁵ Department of Obstetrics and Gynaecology, NHS Greater Glasgow and Clyde, Glasgow, UK.
⁶ Northern Gynaecological Oncology Centre, Gateshead Health NHS Foundation Trust, Gateshead, UK.
⁷ Department of Gynaecological Oncology, Grace Centre, Musgrove Park Hospital, Taunton, UK.
⁸ Department of Oncology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
⁹ University of Bath, Bath, UK.
¹⁰ Reproductive Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.
¹¹ Department of Gynaecological Oncology, Royal Devon University NHS Foundation Trust, Exeter, UK.
¹² Department of Surgery and Cancer, Imperial College, London University, London, UK.
¹³ St Erme Medical, Truro, UK.
¹⁴ Jo's Trust Charity, London, UK.
¹⁵ Ovacome Ovarian Cancer Charity, London, UK.
¹⁶ Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
¹⁷ Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.
¹⁸ Department of Gynaecology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
¹⁹ Department of Medical Oncology, University College Hospital, London, UK.
²⁰ University College London, London, UK.
²¹ Derby Gynaecological Cancer Centre, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
²² Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.

PMID: 39394654
DOI: 10.1177/20533691241286666

Practice Guideline

British Gynaecological Cancer Society and British Menopause Society guidelines: Management of menopausal symptoms following treatment of gynaecological cancer

Alexandra Taylor et al. Post Reprod Health. 2024 Dec.

. 2024 Dec;30(4):256-279.

doi: 10.1177/20533691241286666. Epub 2024 Oct 11.

Authors

Affiliations

¹ Department of Gynaecology Oncology, The Royal Marsden Hospital NHS Trust, London, UK.
² The Institute of Cancer Research, London, UK.
³ Department of Gynaecology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
⁴ Department of Gynaecology, University Hospitals Dorset NHS Foundation Trust, Poole, UK.
⁵ Department of Obstetrics and Gynaecology, NHS Greater Glasgow and Clyde, Glasgow, UK.
⁶ Northern Gynaecological Oncology Centre, Gateshead Health NHS Foundation Trust, Gateshead, UK.
⁷ Department of Gynaecological Oncology, Grace Centre, Musgrove Park Hospital, Taunton, UK.
⁸ Department of Oncology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.
⁹ University of Bath, Bath, UK.
¹⁰ Reproductive Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.
¹¹ Department of Gynaecological Oncology, Royal Devon University NHS Foundation Trust, Exeter, UK.
¹² Department of Surgery and Cancer, Imperial College, London University, London, UK.
¹³ St Erme Medical, Truro, UK.
¹⁴ Jo's Trust Charity, London, UK.
¹⁵ Ovacome Ovarian Cancer Charity, London, UK.
¹⁶ Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
¹⁷ Department of Gynaecological Oncology, Barts Health NHS Trust, London, UK.
¹⁸ Department of Gynaecology, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
¹⁹ Department of Medical Oncology, University College Hospital, London, UK.
²⁰ University College London, London, UK.
²¹ Derby Gynaecological Cancer Centre, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
²² Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.

PMID: 39394654
DOI: 10.1177/20533691241286666

Abstract

These guidelines have been developed jointly by the British Gynaecological Cancer Society and British Menopause Society to provide information for all healthcare professionals managing women treated for gynaecological cancer. Menopausal symptoms can have a significant impact on quality of life for women. Cancer therapies, including surgery, pelvic radiotherapy, chemotherapy and endocrine therapy, can all affect ovarian function. The benefits and risks of using hormone replacement therapy are considered by cancer type with guidance on the type of HRT and optimal time of commencement after cancer treatment. Vaginal estrogens can be very effective for improving urogenital symptoms and are safe for the majority of women, including those for whom systemic HRT is contraindicated with rare exceptions. Alternative options to HRT are reviewed including pharmacological and non-pharmacological approaches.

Keywords: Menopause; alternative therapies; gynaecological cancer; hormone replacement therapy.

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Conflict of interest statement

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: RM: Grants from GSK, NHS England, Yorkshire Cancer Research, Barts Charity, Rosetrees Trust outside the submitted work, and honoraria for advisory board membership from Astrazeneca/MSD/GSK/EGL. RM was clinical lead/topic advisor for NICE Guideline NG241 Ovarian cancer: identifying and managing familial and genetic risk.SG-M: membership of NICE HRT guidelines committee.TH: Consultancy and lecture fees from Astellas. JS: Funding for conference attendance, speaking and advisory board funding from Bayer, Astellas, Gedeon Richter and Theramex.

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British Gynaecological Cancer Society and British Menopause Society guidelines: Management of menopausal symptoms following treatment of gynaecological cancer

Affiliations

British Gynaecological Cancer Society and British Menopause Society guidelines: Management of menopausal symptoms following treatment of gynaecological cancer

Authors

Affiliations

Abstract

Conflict of interest statement

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Full Text Sources

Medical