Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 12:e202400316.
doi: 10.1002/jbio.202400316. Online ahead of print.

High-Resolution Terahertz Spectroscopy for Medical Diagnostics

Vladimir Vaks  1   2 , Elena Domracheva  1   2 , Maria Chernyaeva  1   2 , Vladimir Anfertev  1   2 , Andrey Ayzenshtadt  1   3 , Kseniya Glushkova  1   3 , Aleksandra Cherniaeva  1
Affiliations

High-Resolution Terahertz Spectroscopy for Medical Diagnostics

Vladimir Vaks et al. J Biophotonics. .

Abstract

The metabolomics-based approach to diagnostics and therapy monitoring is a fast-emerging trend in modern medicine. Terahertz nonstationary spectroscopy based on the induction and disintegration of freely decaying polarization in the gas mixture during the interaction of radiation with molecules at resonance frequencies is a high-sensitivity method for studying multicomponent gas mixtures, which is promising for identifying metabolites in the thermal decomposition products of biological samples. The paper presents the results of the application of high-resolution terahertz spectroscopy to the study of biological samples taken from patients with certain diseases (pathologically changed tissues of ear-nose-throat organs and similar pathologic tissues formed in other life support systems) to search for characteristic sets of metabolites characterizing the pathology. The world's first measurements of the spectra of pathologic samples of cysts, formed in different life support systems, were carried out, which made it possible to identify similar substances in tissues having the same pathology.

Keywords: THz high‐resolution spectroscopy; biological tissues; cysts; ear‐nose‐throat organs; metabolites; thermal decomposition.

PubMed Disclaimer

References

    1. “Metabolites,” accessed May 2024, https://www.mdpi.com/journal/metabolites.
    1. D. S. Wishart, Y. D. Feunang, A. Marcu, and A. C. Guo, “HMDB 4.0: The Human Metabolome Database for 2018,” Nucleic Acids Research 46 (2018): 29140435.
    1. A. Matsui, H. T. Psacharopoulos, A. P. Mowat, B. Portmann, and G. M. Murphy, “Radioimmunoassay of Serum Glycocholic Acid, Standard Laboratory Tests of Liver Function and Liver Biopsy Findings: Comparative Study of Children With Liver Disease,” Journal of Clinical Pathology 35 (1982): 1011–1017.
    1. J. Shi, Z. Yi, L. Jin, et al., “Cyst Fluid Metabolites Distinguish Malignant From Benign Pancreatic Cysts,” Neoplasia 23 (2021): 1078–1088.
    1. A. Noto, C. Piras, L. Atzori, et al., “Metabolomics in Otorhinolaryngology,” Frontiers in Molecular Biosciences 9 (2022): 934311.

LinkOut - more resources