Circadian (diurnal/nocturnal) pattern of cardiac arrhythmias

Abstract

Circadian rhythms follow 24-hour biological cycle patterns controlled by internal biological or circadian clocks that optimize organismal homeostasis according to predictable environmental changes. These clocks are found in virtually all cells in the body, including cardiomyocytes. Triggers for and/or the occurrence of sudden cardiac death (SCD) and cardiac arrhythmias seem to follow such daily patterns. This review highlights data from studies exploring the role of day/night rhythms in the timing of arrhythmic events, studies describing the environmental, behavioral, and circadian mechanisms regulating cardiac electrophysiology focusing on the circadian pattern of arrhythmias and SCD. Mechanisms involved relate to circadian control of electrophysiological properties, vagal tone, and sleep disorders, as well as the potential interaction and synergism among these factors. By studying the diurnal variations of arrhythmias, therapy can be improved by optimally timing it to their circadian pattern and a person's internal body clock time. Potential treatment targets for arrhythmias with nocturnal onset may include upstream therapy for underlying comorbidities, type and timing of drug intake, pulmonary vein isolation, ablation of the ganglionated plexus, and autonomic nervous system control. Thus, specific history-taking, screening, and diagnostic workup are recommended to identify and characterize comorbidities and potential contributors to nocturnal arrhythmias, such as obesity, advanced age, diabetes, hypertension, and heart failure. In this direction, symptoms of sleep apnea may comprise snoring and excessive daytime sleepiness. Risk factors include obesity, decreased upper airway dimensions, and heart failure. Thus, one should have a low threshold for sleep testing to assess for sleep apnea. Sleep apnea treatment decreases ventricular arrhythmias and ameliorates some severe bradycardic episodes, often obviating the need for pacemaker implantation. Importantly, comorbidity treatment and lifestyle optimization remain crucial.

Keywords: Atrial fibrillation; Atrioventricular block; Brugada syndrome; Implantable cardioverter-defibrillator; Nocturnal arrhythmia; Permanent pacemaker; Sinus bradycardia; Sleep apnea; Sudden death; Ventricular arrhythmia.