Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum

David Kavanagh¹, Gianluigi Ardissino², Vicky Brocklebank³, Romy N Bouwmeester⁴, Arvind Bagga⁵, Rob Ter Heine⁶, Sally Johnson⁷, Christoph Licht⁸, Alison L T Ma⁹, Marina Noris¹⁰, Manuel Praga¹¹, Eric Rondeau¹², Aditi Sinha⁵, Richard J H Smith¹³, Neil S Sheerin³, H Trimarchi¹⁴, Jack F M Wetzels¹⁵, Marina Vivarelli¹⁶, Nicole C A J Van de Kar⁴, Larry A Greenbaum¹⁷; Forum Participants

Collaborators, Affiliations

Collaborators

Forum Participants:
Adrian Catalin Lungu¹⁸, Aleksandra Żurowska¹⁹, Alexandra Gerogianni²⁰, Anne Durkan²¹, Anne Schijvens²², Anne-Laure Lapeyraque²³, Anuja Java²⁴, Atif Awan²⁵, Bianca Covella²⁶, Bradley P Dixon²⁷, Carine El Sissy²⁸, Caroline Duinevel²², Christine Maville²⁹, Daniel Turudic³⁰, Diana Karpman³¹, Dieter Haffner³², Elżbieta Trembecka-Dubel³³, Fatih Ozaltin³⁴, Francesco Emma³⁵, Franz Schaefer³⁶, Hee Gyung Kang³⁷, Hernán Trimarchi³⁸, Hernando Trujillo³⁹, Ifeoma Ulasi⁴⁰, Alex Ekwueme⁴¹, Jan Menne⁴², Jeffrey Laurence⁴³, Joaquim Calado⁴⁴, Johannes Hofer⁴⁵, Julien Zuber⁴⁶, Jun Oh⁴⁷, Karmila Abu Bakar⁴⁸, Kate Smith Jackson⁴⁹, Daniel Turudic³⁰, Danko Milosevic⁵⁰, Diana Karpman⁵¹, Elżbieta Trembecka-Dubel³³, Fatih Ozaltin³⁴, Francesco Emma³⁵, Franz Schaefer³⁶, Gema Ariceta⁵², Hee Gyung Kang³⁷, Hernán Trimarchi³⁸, Hernando Trujillo³⁹, Ifeoma Ulasi⁴⁰, Alex Ekwueme⁴¹, Jan Menne⁴², Jeffrey Laurence⁴³, Joaquim Calado⁵³, Kathleen J Claes⁵⁴, Kati Kaartinen⁵⁵, Khalid Alhasan⁵⁶, Kioa Wijnsma²², L P van den Heuvel²², Laura Alconcher⁵⁷, Maria Izabel de Holanda⁵⁸, Maria Szczepańska³³, Marie-Sophie Meuleman⁵⁹, Mathieu Lemaire⁶⁰, Meredith Harris⁶¹, Michael G Michalopulos⁶², Michal Malina⁴⁹, Mihály Józsi⁶³, Nataša Stajić⁶⁴, Nicole Isbel⁶⁵, Patrick Walsh⁶⁶, Paula A Coccia⁶⁷, Raja Ramachandran⁶⁸, Rezan Topaloglu⁶⁹, Sjoerd A M E G Timmermans⁷⁰, Sophie Chauvet⁷¹, Tanja Kersnik Levart⁷², Tomas Seeman⁷³, Velibor Tasic⁷⁴, Vladimír Tesař⁷⁵, Wen-Chao Song⁷⁶, Yuzhou Zhang⁷⁷, Zoltán Prohászka⁷⁸

Affiliations

¹ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: david.kavanagh@ncl.ac.uk.
² Center for Hemolytic Uremic Syndrome (HUS) Prevention, Pediatric Nephrology, Dialysis and Transplantation Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
³ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
⁴ Radboud University Medical Center, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Nijmegen, The Netherlands.
⁵ Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
⁶ Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Great North Children's Hospital, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
⁸ Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
⁹ Paediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong, China; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
¹⁰ Istituto di Ricerche Farmacologiche Mario Negri Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Ranica, Italy.
¹¹ Department of Nephrology, Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain; Medicine Department, Universidad Complutense de Madrid, Madrid, Spain.
¹² Intensive Care Nephrology and Transplantation Department, Assistance Publique des Hôpitaux de Paris (AP-HP) - Sorbonne Université, Paris, France.
¹³ Molecular Otolaryngology and Renal Research Laboratories, The University of Iowa, Iowa City, Iowa, USA.
¹⁴ Nephrology Service, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina.
¹⁵ Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
¹⁶ Division of Nephrology, Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
¹⁷ Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: lgreen6@emory.edu.
¹⁸ Fundeni Clinical Institute, Bucharest.
¹⁹ Medical University Gdańsk, Gdańsk.
²⁰ Lund University, Lund; Amanda Dickens Starship Children's Hospital, Auckland.
²¹ The Children's Hospital at Westmead, University of Sydney, Sydney.
²² Radboud University Medical Center (Radboudumc), Nijmegen.
²³ CHU Sainte Justine, Montreal University, Montreal, Québec.
²⁴ Washington University School of Medicine, St. Louis, Missouri.
²⁵ Children's Health Ireland at Temple Street, Dublin.
²⁶ Miulli General Hospital, Acquaviva delle Fonti (Bari) Italy.
²⁷ University of Colorado School of Medicine, Aurora.
²⁸ Hôpital Européen Georges Pompidou AP-HP, Paris, Carla Nester, University of Iowa, Stead Family Children's Hospital, Iowa City.
²⁹ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne.
³⁰ University Hospital Centre Zagreb, Zagreb.
³¹ Lund University, Lund.
³² Children's Hospital, Hannover Medical School, Hanover.
³³ Medical University of Silesia, Katowice.
³⁴ Hacettepe University Faculty of Medicine, Ankara.
³⁵ Bambino Gesù Children's Hospital - IRCCS, Rome.
³⁶ Heidelberg University, Heidelberg.
³⁷ Seoul National University Children's Hospital, Seoul, and Seoul National University College of Medicine, Seoul.
³⁸ Hospital Britanico de Buenos Aires, Buenos Aires.
³⁹ Hospital Universitario 12 de Octubre, Madrid.
⁴⁰ University of Nigeria, University of Nigeria Teaching Hospital, Nigeria.
⁴¹ Federal University Teaching Hospital, Enugu, and Inês Aires Hospital Curry Cabral - CHULC, Lisbon.
⁴² KRH Klinikum Mitte - Standort Siloah, Hannover.
⁴³ Weill Cornell Medicine, New York, New York.
⁴⁴ NOVA Medical School, Universidade Nova de Lisboa, Lisbon; Hospital of St. John of God, Perth, and Johannes Kepler University Linz, Linz.
⁴⁵ Hospital of St. John of God, Perth, and Johannes Kepler University Linz, Linz.
⁴⁶ Necker Hospital, Paris Cité University, Paris.
⁴⁷ University Medical Center Hamburg/Eppendorf, Hamburg.
⁴⁸ University of Malaya, Kuala Lumpur.
⁴⁹ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle-upon-Tyne, and Newcastle University, Newcastle upon Tyne.
⁵⁰ University of Zagreb School of Medicine, Zagreb, and Croatian Academy of Medical Sciences, Zagreb.
⁵¹ Lund University, Lund; Dieter Haffner, Children's Hospital, Hannover Medical School, Hanover.
⁵² Hospital Vall d'Hebron, Barcelona, and Autonomous University of Barcelona, Barcelona.
⁵³ NOVA Medical School, Universidade Nova de Lisboa, Lisbon.
⁵⁴ UZ Leuven, KU Leuven, Leuven.
⁵⁵ HUS Helsinki University Hospital, Helsinki.
⁵⁶ King Saud University; King Faisal Specialist Hospital, Riyadh, and Research Center, Riyadh.
⁵⁷ Hospital Interzonal General Dr. José Penna, Bahía Blanca.
⁵⁸ Hospital Federal de Bonsucesso, Rio de Janeiro.
⁵⁹ Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, Paris.
⁶⁰ The Hospital for Sick Children, Toronto, Sick Kids Research Institute, Toronto, and University of Toronto, Toronto.
⁶¹ Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago.
⁶² UT Southwestern Dallas, Texas.
⁶³ ELTE Eötvös Loránd University, Budapest, and Hungarian Research Network, Budapest.
⁶⁴ Institute of Mother and Child Health Care of Serbia "Dr Vukan Čupić," Belgrade.
⁶⁵ Princess Alexandra Hospital, Brisbane, and University of Queensland, Brisbane.
⁶⁶ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle-upon-Tyne, and Newcastle University, Newcastle-upon-Tyne.
⁶⁷ Hospital Italiano de Buenos Aires, Buenos Aires.
⁶⁸ Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh.
⁶⁹ Hacettepe University School of Medicine, Ankara.
⁷⁰ Maastricht University Medical Center, Maastricht.
⁷¹ Georges Pompidou Hospital, APHP, Paris.
⁷² University Medical Centre Ljubljana, Ljubljana.
⁷³ Second Faculty of Medicine of Charles University, Prague, and University of Ostrava, Ostrava.
⁷⁴ University Children's Hospital, Skopje.
⁷⁵ General University Hospital, Prague, and Charles University, Prague.
⁷⁶ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁷⁷ University of Iowa, Iowa City.
⁷⁸ Semmelweis University, Budapest.

PMID: 39395628
PMCID: PMC12365746
DOI: 10.1016/j.kint.2024.09.012

Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum

David Kavanagh et al. Kidney Int. 2024 Dec.

. 2024 Dec;106(6):1038-1050.

doi: 10.1016/j.kint.2024.09.012. Epub 2024 Oct 10.

Authors

Collaborators

Forum Participants:
Adrian Catalin Lungu¹⁸, Aleksandra Żurowska¹⁹, Alexandra Gerogianni²⁰, Anne Durkan²¹, Anne Schijvens²², Anne-Laure Lapeyraque²³, Anuja Java²⁴, Atif Awan²⁵, Bianca Covella²⁶, Bradley P Dixon²⁷, Carine El Sissy²⁸, Caroline Duinevel²², Christine Maville²⁹, Daniel Turudic³⁰, Diana Karpman³¹, Dieter Haffner³², Elżbieta Trembecka-Dubel³³, Fatih Ozaltin³⁴, Francesco Emma³⁵, Franz Schaefer³⁶, Hee Gyung Kang³⁷, Hernán Trimarchi³⁸, Hernando Trujillo³⁹, Ifeoma Ulasi⁴⁰, Alex Ekwueme⁴¹, Jan Menne⁴², Jeffrey Laurence⁴³, Joaquim Calado⁴⁴, Johannes Hofer⁴⁵, Julien Zuber⁴⁶, Jun Oh⁴⁷, Karmila Abu Bakar⁴⁸, Kate Smith Jackson⁴⁹, Daniel Turudic³⁰, Danko Milosevic⁵⁰, Diana Karpman⁵¹, Elżbieta Trembecka-Dubel³³, Fatih Ozaltin³⁴, Francesco Emma³⁵, Franz Schaefer³⁶, Gema Ariceta⁵², Hee Gyung Kang³⁷, Hernán Trimarchi³⁸, Hernando Trujillo³⁹, Ifeoma Ulasi⁴⁰, Alex Ekwueme⁴¹, Jan Menne⁴², Jeffrey Laurence⁴³, Joaquim Calado⁵³, Kathleen J Claes⁵⁴, Kati Kaartinen⁵⁵, Khalid Alhasan⁵⁶, Kioa Wijnsma²², L P van den Heuvel²², Laura Alconcher⁵⁷, Maria Izabel de Holanda⁵⁸, Maria Szczepańska³³, Marie-Sophie Meuleman⁵⁹, Mathieu Lemaire⁶⁰, Meredith Harris⁶¹, Michael G Michalopulos⁶², Michal Malina⁴⁹, Mihály Józsi⁶³, Nataša Stajić⁶⁴, Nicole Isbel⁶⁵, Patrick Walsh⁶⁶, Paula A Coccia⁶⁷, Raja Ramachandran⁶⁸, Rezan Topaloglu⁶⁹, Sjoerd A M E G Timmermans⁷⁰, Sophie Chauvet⁷¹, Tanja Kersnik Levart⁷², Tomas Seeman⁷³, Velibor Tasic⁷⁴, Vladimír Tesař⁷⁵, Wen-Chao Song⁷⁶, Yuzhou Zhang⁷⁷, Zoltán Prohászka⁷⁸

Affiliations

¹ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: david.kavanagh@ncl.ac.uk.
² Center for Hemolytic Uremic Syndrome (HUS) Prevention, Pediatric Nephrology, Dialysis and Transplantation Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
³ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
⁴ Radboud University Medical Center, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Nijmegen, The Netherlands.
⁵ Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
⁶ Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
⁷ National Renal Complement Therapeutics Centre, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom; Great North Children's Hospital, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
⁸ Division of Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
⁹ Paediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong, China; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
¹⁰ Istituto di Ricerche Farmacologiche Mario Negri Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Ranica, Italy.
¹¹ Department of Nephrology, Instituto de Investigación Hospital 12 de Octubre (imas12), Madrid, Spain; Medicine Department, Universidad Complutense de Madrid, Madrid, Spain.
¹² Intensive Care Nephrology and Transplantation Department, Assistance Publique des Hôpitaux de Paris (AP-HP) - Sorbonne Université, Paris, France.
¹³ Molecular Otolaryngology and Renal Research Laboratories, The University of Iowa, Iowa City, Iowa, USA.
¹⁴ Nephrology Service, Hospital Britanico de Buenos Aires, Buenos Aires, Argentina.
¹⁵ Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
¹⁶ Division of Nephrology, Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
¹⁷ Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: lgreen6@emory.edu.
¹⁸ Fundeni Clinical Institute, Bucharest.
¹⁹ Medical University Gdańsk, Gdańsk.
²⁰ Lund University, Lund; Amanda Dickens Starship Children's Hospital, Auckland.
²¹ The Children's Hospital at Westmead, University of Sydney, Sydney.
²² Radboud University Medical Center (Radboudumc), Nijmegen.
²³ CHU Sainte Justine, Montreal University, Montreal, Québec.
²⁴ Washington University School of Medicine, St. Louis, Missouri.
²⁵ Children's Health Ireland at Temple Street, Dublin.
²⁶ Miulli General Hospital, Acquaviva delle Fonti (Bari) Italy.
²⁷ University of Colorado School of Medicine, Aurora.
²⁸ Hôpital Européen Georges Pompidou AP-HP, Paris, Carla Nester, University of Iowa, Stead Family Children's Hospital, Iowa City.
²⁹ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne.
³⁰ University Hospital Centre Zagreb, Zagreb.
³¹ Lund University, Lund.
³² Children's Hospital, Hannover Medical School, Hanover.
³³ Medical University of Silesia, Katowice.
³⁴ Hacettepe University Faculty of Medicine, Ankara.
³⁵ Bambino Gesù Children's Hospital - IRCCS, Rome.
³⁶ Heidelberg University, Heidelberg.
³⁷ Seoul National University Children's Hospital, Seoul, and Seoul National University College of Medicine, Seoul.
³⁸ Hospital Britanico de Buenos Aires, Buenos Aires.
³⁹ Hospital Universitario 12 de Octubre, Madrid.
⁴⁰ University of Nigeria, University of Nigeria Teaching Hospital, Nigeria.
⁴¹ Federal University Teaching Hospital, Enugu, and Inês Aires Hospital Curry Cabral - CHULC, Lisbon.
⁴² KRH Klinikum Mitte - Standort Siloah, Hannover.
⁴³ Weill Cornell Medicine, New York, New York.
⁴⁴ NOVA Medical School, Universidade Nova de Lisboa, Lisbon; Hospital of St. John of God, Perth, and Johannes Kepler University Linz, Linz.
⁴⁵ Hospital of St. John of God, Perth, and Johannes Kepler University Linz, Linz.
⁴⁶ Necker Hospital, Paris Cité University, Paris.
⁴⁷ University Medical Center Hamburg/Eppendorf, Hamburg.
⁴⁸ University of Malaya, Kuala Lumpur.
⁴⁹ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle-upon-Tyne, and Newcastle University, Newcastle upon Tyne.
⁵⁰ University of Zagreb School of Medicine, Zagreb, and Croatian Academy of Medical Sciences, Zagreb.
⁵¹ Lund University, Lund; Dieter Haffner, Children's Hospital, Hannover Medical School, Hanover.
⁵² Hospital Vall d'Hebron, Barcelona, and Autonomous University of Barcelona, Barcelona.
⁵³ NOVA Medical School, Universidade Nova de Lisboa, Lisbon.
⁵⁴ UZ Leuven, KU Leuven, Leuven.
⁵⁵ HUS Helsinki University Hospital, Helsinki.
⁵⁶ King Saud University; King Faisal Specialist Hospital, Riyadh, and Research Center, Riyadh.
⁵⁷ Hospital Interzonal General Dr. José Penna, Bahía Blanca.
⁵⁸ Hospital Federal de Bonsucesso, Rio de Janeiro.
⁵⁹ Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité, Paris.
⁶⁰ The Hospital for Sick Children, Toronto, Sick Kids Research Institute, Toronto, and University of Toronto, Toronto.
⁶¹ Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago.
⁶² UT Southwestern Dallas, Texas.
⁶³ ELTE Eötvös Loránd University, Budapest, and Hungarian Research Network, Budapest.
⁶⁴ Institute of Mother and Child Health Care of Serbia "Dr Vukan Čupić," Belgrade.
⁶⁵ Princess Alexandra Hospital, Brisbane, and University of Queensland, Brisbane.
⁶⁶ Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle-upon-Tyne, and Newcastle University, Newcastle-upon-Tyne.
⁶⁷ Hospital Italiano de Buenos Aires, Buenos Aires.
⁶⁸ Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh.
⁶⁹ Hacettepe University School of Medicine, Ankara.
⁷⁰ Maastricht University Medical Center, Maastricht.
⁷¹ Georges Pompidou Hospital, APHP, Paris.
⁷² University Medical Centre Ljubljana, Ljubljana.
⁷³ Second Faculty of Medicine of Charles University, Prague, and University of Ostrava, Ostrava.
⁷⁴ University Children's Hospital, Skopje.
⁷⁵ General University Hospital, Prague, and Charles University, Prague.
⁷⁶ Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁷⁷ University of Iowa, Iowa City.
⁷⁸ Semmelweis University, Budapest.

PMID: 39395628
PMCID: PMC12365746
DOI: 10.1016/j.kint.2024.09.012

Abstract

Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.

Keywords: C5; acute kidney injury; complement; hemolytic uremic syndrome; thrombotic microangiopathy.

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Figures

**Figure 1:. Classification thrombotic microangiopathies**
Abbreviations: AAV, ANCA (anti-neutrophil cytoplasmic antibody) associated vasculitis; ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; *ACTN4*, Actinin 4; aHUS, atypical haemolytic uraemic syndrome; C3G, C3 glomerulopathy; CAPS, catastrophic antiphospholipid syndrome; *EXOSC3*, exosome component 3; *DGKE*, gene encoding diacylglycerol kinase Ɛ; FH, factor H; FSGS, focal segmental glomerulosclerosis; HELLP, syndrome of haemolysis, elevated liver enzymes and low platelets; HIV, human immunodeficiency virus; HUS, haemolytic uraemic syndrome; *HSD11B2*, 1-beta-hydroxysteroid dehydrogenase; IgAN, IgA nephropathy; *INF2*, Inverted formin 2; MN, membranous nephropathy; MPGN, membranoproliferative glomerulonephritis; *MTHFD1*, methylenetetrahydrofolate dehydrogenase 1; *MMACHC*, methylmalonic aciduria and homocystinuria cblC type; *MTR*, 5-methyltetrahydrofolate-homocysteine S-methyltransferase; *NPHS2*, Podocin; SLE, systemic lupus erythematosus; SRC, scleroderma renal crisis; STEC, shiga toxin producing *Escherichia coli;* TMA, thrombotic microangiopathy; TTP, thrombotic thrombocytopenic purpura; *TSEN2*, tRNA splicing endonuclease subunit 2; *WT1*, WT1 transcription factor. Modified with permission from

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References

1. Brocklebank V, Wood KM, Kavanagh D. Thrombotic Microangiopathy and the Kidney. Clin J Am Soc Nephrol. 2018;13(2):300–317. - PMC - PubMed
1. Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013;368(23):2169–2181. - PubMed
1. Barbour T, Scully M, Ariceta G, et al. Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults. Kidney Int Rep. 2021;6(6):1603–1613. - PMC - PubMed
1. Nester C, Feldman DL, Burwick R, et al. An Expert Discussion on the Atypical Hemolytic Uremic Syndrome Nomenclature - Identifying a Roadmap to Precision: A Report of a National Kidney Foundation Working Group. Kidney Int. 2024;in press. - PubMed
1. Brocklebank V, Walsh PR, Smith-Jackson K, et al. Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study. Blood. 2023;142(16):1371–1386. - PMC - PubMed

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Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum

Collaborators

Affiliations

Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum

Authors

Collaborators

Affiliations

Abstract

Figures

References

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous