Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 12;24(1):665.
doi: 10.1186/s12884-024-06846-9.

Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy

Mingming Xu  1 , Linlin Tang  1 , Yaping Wang  2
Affiliations

Fluctuation trend of inflammatory indexes related to gestational diabetes mellitus from second trimester to third trimester of pregnancy

Mingming Xu et al. BMC Pregnancy Childbirth. .

Abstract

Objective: This study aims to assess the prognostic and diagnostic value of inflammatory indexes related to gestational diabetes mellitus (GDM) from the second trimester to the third trimester of pregnancy.

Materials and methods: In this study, we randomly selected 65 pregnant women diagnosed with GDM at our hospital from December 2022 to June 2023 to form the GDM group (n = 65). Additionally, 65 pregnant women at the same gestational weeks without GDM were selected as the Normal group (n = 65). We collected gestational information and serum samples at 24 and 36 weeks of gestation from the participants. The levels of NLRP3, IL-1Ra, and TBP-2 were determined using enzyme-linked immunosorbent assay (ELISA) to explore their changes during pregnancy. Further, this study analyzed the changes in the levels of NLRP3, IL-1Ra, and TBP-2 at 24 and 36 weeks of gestation in GDM patients and their correlation with gestational diabetes mellitus.

Results: The study showed that pre-pregnancy body mass index (BMI), neonatal weight, gestational hypertension, and macrosomia are significantly associated with the occurrence of GDM (P < 0.05). Statistical analysis comparing the normal and GDM groups found no significant changes in the levels of NLRP3, IL-1Ra, and TBP-2 with the progression of gestation in the normal group. In contrast, in the GDM group, the levels of IL-1Ra in serum samples at 24 and 36 weeks were significantly increased (P < 0.05) while the levels of NLRP3 and TBP-2 were significantly reduced (P < 0.05). At 36 weeks, there was a positive correlation between the levels of NLRP3, IL-1Ra, and TBP-2. Compared to the normal group, the overall levels of NLRP3, IL-1Ra, and TBP-2 in the GDM group were lower (P < 0.05) and the weight of the newborns was significantly correlated with these three indicators (P < 0.05), specifically newborn weight increased with the levels of NLRP3 and TBP-2 but decreased with the increase of IL-1Ra (P < 0.05). Multifactorial logistic regression analysis further revealed that NLRP3 is an independent factor influencing GDM (P < 0.05). ROC curve analysis of the NLRP3 level at 24 weeks of gestation found that NLRP3 has a good value in predicting GDM (AUC = 0.720, 95%CI 0.630-0.809, P < 0.001) and the combined prediction of NLRP3, IL-1Ra, and TBP-2 also showed a good predictive value for GDM.

Conclusion: The changes in NLRP3, IL-1Ra, and TBP-2 persisted throughout the 24 to 36 weeks of gestation, playing an important role in predicting the occurrence of GDM and the weight of the newborn.

Keywords: Gestational diabetes mellitus; IL-1Ra; NLRP3; TBP-2.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
ROC curve of GDM predicted by NLRP3, TBP-2 and IL-1Ra at 24 weeks of pregnancy
Fig. 2
Fig. 2
combined prediction of ROC curve of GDM by NLRP3, IL-1Ra and TBP-2 at 24 weeks of pregnancy
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Gao C, Sun X, Lu L, Liu F, Yuan J. Prevalence of gestational diabetes mellitus in mainland China: a systematic review and meta-analysis. J Diabetes Investig. 2019;10(1):154–62. 10.1111/jdi.12854. Epub 2018 May 27. PMID: 29683557; PMCID: PMC6319492. - PMC - PubMed
    1. Ye W, Luo C, Huang J, Li C, Liu Z, Liu F. Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2022;377:e067946. 10.1136/bmj-2021-067946. PMID: 35613728; PMC9ID: PMC131781. - PMC - PubMed
    1. Yingying H, Chu Qian. Correlation between indicators related to islet function during pregnancy and postpartum glucose tolerance in pregnant women with GDM [J]. Progress Mod Obstet Gynecol. 2023;32(07):535–7.
    1. Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes Mellitus. Int J Mol Sci. 2018;19(11):3342. 10.3390/ijms19113342. PMID: 30373146; PMCID: PMC6274679. - PMC - PubMed
    1. Juan J, Yang H, Prevalence. Prevention, and Lifestyle intervention of gestational diabetes Mellitus in China. Int J Environ Res Public Health. 2020;17(24):9517. 10.3390/ijerph17249517. PMID: 33353136; PMCID: PMC7766930. - PMC - PubMed

Substances

LinkOut - more resources