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. 2024 Oct 12;13(1):256.
doi: 10.1186/s13643-024-02675-1.

Efficacy of pharmacological interventions for ADHD: protocol for an updated systematic review and dose-response network meta-analysis

Mikail Nourredine  1   2   3 , Lucie Jurek  4   5   6 , Georgia Salanti  7 , Andrea Cipriani  8   9   10 , Fabien Subtil  11   12 , Orestis Efthimiou  7   13 , Tasnim Hamza  7 , Samuele Cortese  4   10   13   14   15   16
Affiliations

Efficacy of pharmacological interventions for ADHD: protocol for an updated systematic review and dose-response network meta-analysis

Mikail Nourredine et al. Syst Rev. .

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) affects approximately 5% of children globally, with symptoms often persisting into adulthood. While pharmacological interventions are commonly employed for management, understanding the optimal dosing for efficacy and tolerability remains crucial. This study aims to conduct a dose-response network meta-analysis to estimate the efficacy of pharmacological treatments across different doses, aiming to inform clinical decision-making and improve treatment outcomes.

Methods: This updated systematic review will include randomized controlled trials evaluating ADHD medication efficacy in children, adolescents, and adults. An updated search from a 2018 NMA will be conducted across multiple electronic databases with no language restrictions, using specific eligibility criteria focused on randomized controlled trials. The primary outcome will assess the severity of ADHD core symptoms, while secondary outcomes will consider treatment tolerability. A dose-response Bayesian hierarchical model will be used to estimate dose-response curves for each medication, identifying optimal dosing strategies.

Discussion: With this dose-response network meta-analysis, we aim to better understand the dose-response relationship of pharmacological treatment in ADHD, which could help clinician to the identification of optimal doses.

Systematic review registration: OSF https://doi.org/10.17605/OSF.IO/3MY4A .

Keywords: Attention deficit/hyperactivity disorder; Dose-responsenetwork meta-analysis; Pharmacotherapy.

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Conflict of interest statement

M. N., L. J., G. S., A. C., F. S., O. E., and T. H. declare that they have no competing interests. S. C. has declared reimbursement for travel and accommodation expenses from the Association for Child and Adolescent Central Health (ACAMH) in relation to lectures delivered for ACAMH, the Canadian AADHD Alliance Resource, the British Association of Psychopharmacology, and from Healthcare Convention for educational activity on ADHD and has received honoraria from Medice

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