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. 2024 Dec 17;79(6):1333-1337.
doi: 10.1093/cid/ciae487.

The Heterogeneous Syndrome of Noninfectious Causes of Persistent Fever in Neutropenic Patients With Hematologic Malignancy: Another Opportunity for Stewardship?

Abdullah Tarik Aslan  1 , Murat Akova  2 , Dimitrios P Kontoyiannis  3
Affiliations

The Heterogeneous Syndrome of Noninfectious Causes of Persistent Fever in Neutropenic Patients With Hematologic Malignancy: Another Opportunity for Stewardship?

Abdullah Tarik Aslan et al. Clin Infect Dis. .

Abstract

Although occult fungal, viral, and multidrug-resistant bacterial infections can cause persistent fever in neutropenic patients with hematologic cancer, a variety of noninfectious entities should be considered on a case-by-case basis in the context of negative diagnostic workup for infection.

Keywords: cytokine release syndrome; febrile neutropenia; hemophagocytic lymphohistiocytosis; postengraftment syndrome; tumor fever.

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Conflict of interest statement

Potential conflicts of interest. M. A. reports research support from Pfizer and Gilead, and was also a member of the data review committee of GSK. D. P. K. reports honoraria and research support from Gilead Sciences and Astellas Pharma; received consultant fees from Astellas Pharma, Merck, Gilead Sciences, and Knight; and is a member of the data review committee of Cidara Therapeutics, AbbVie, Scynexis, and the Mycoses Study Group. A. T. A. reports no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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