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Review
. 2024 Oct 14:26:e27.
doi: 10.1017/erm.2024.28.

Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy

Jinghan Cai  1 , Yan Xu  2 , Fei Liao  3
Affiliations
Review

Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy

Jinghan Cai et al. Expert Rev Mol Med. .

Abstract

Cancer remains a significant threat to human health today. Even though starvation therapy and other treatment methods have recently advanced to a new level of rapid development in tumour treatment, their limited therapeutic effectiveness and unexpected side effects prevent them from becoming the first option in clinical treatment. With rapid advancement in nanotechnology, the utilization of nanomaterials in therapeutics offers the potential to address the shortcomings in cancer treatment. Notably, multifunctional metal-organic framework (MOF) has been widely employed in cancer therapy due to their customizable shape, adjustable diameter, high porosity, diverse compositions, large specific surface area, high degree of functionalization and strong biocompatibility. This paper reviews the current progress and success of MOF-based multifunctional nanoplatforms for cancer starvation therapy, as well as the prospects and potential barriers for the application of MOF nanoplatforms in cancer starvation therapy.

Keywords: biomaterials; cancer starvation therapy; metal-organic framework; nanomaterials; tumour.

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Conflict of interest statement

All authors read and approved the final manuscript. They declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
(By FigDraw) We can construct MOF-based nanoplatforms, which use MOF materials to package substances like GOD, PLT, Anti-VGEF2, etc., to enable targeted treatment of tumour cells, causing apoptosis through starvation therapy. Note: MOF, metal-organic framework; GOD, glucose oxidase; PLT, platelet; Anti-VGEF2, anti-vascular endothelial growth factor receptor-2.
Figure 2.
Figure 2.
(By FigDraw) (A) The types of bio-chemotherapy. (B) MOF-based nanoplatforms mediated starvation therapy combined with physical therapy to kill tumour cells. Note: MOF, multifunctional metal-organic framework; CDT, chemodynamical therapy.
Figure 3.
Figure 3.
(By FigDraw) Mechanism of tumour cell killing with ⋅OH produced by the Fenton reaction.
Figure 4.
Figure 4.
(By FigDraw) (A) The types of physiotherapy. (B) MOF-based nanoplatforms mediated starvation therapy combined with physical therapy to kill tumour cells. Note: MOF, multifunctional metal-organic framework; PDT, photodynamic therapy; PTT, photothermal therapy; SDT, sonodynamic therapy.
Figure 5.
Figure 5.
(By FigDraw) MOF-based nanoplatforms mediated diversified therapies to kill tumour cells. Note: MOF, multifunctional metal-organic framework.
See this image and copyright information in PMC

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