Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 28;10(19):e38210.
doi: 10.1016/j.heliyon.2024.e38210. eCollection 2024 Oct 15.

Psychological problems and their impact on oral mucosal disease patients' quality of life: A cross-sectional study in the Chinese population

Yao Ye  1 , Jinjin Wu  2 , Yuzhe Dai  3 , Yisi Tan  3 , Yiyang You  1 , Jin Tan  4
Affiliations

Psychological problems and their impact on oral mucosal disease patients' quality of life: A cross-sectional study in the Chinese population

Yao Ye et al. Heliyon. .

Abstract

Objectives: We aimed to investigate the presence of common psychological factors (i.e., stress, depression, anxiety) and their impact on the Oral health-related quality of life (OHRQoL) in patients diagnosed with four oral mucosal diseases (OMDs): recurrent aphthous ulcers (RAU), oral lichen planus (OLP), oral leukoplakia (OLK), and oral submucous fibrosis (OSF).

Methods: A total of 229 patients with clinically diagnosed OMDs were enrolled in this study, consisting of 55 RAU, 68 OLK, 50 OLP, and 56 OSF patients. The patients were statistically analyzed for psychological problems and OHRQoL using the Visual Analog Scale (VAS)､ the 5-item Oral Health Impact Profile (OHIP-5) and the Depression Anxiety Stress Scale-21 (DASS-21) scales.

Results: There were 229 valid questionnaires collected, consisting of 83 females and 146 males with a mean age of 45.24 (SD = 11.88) years. Multiple regressions between DASS-21 scores and OHIP-5 scores revealed generally negative impacts of psychological problems on OHRQoL, with depression on OLP (β = 0.47), OLK (β = 0.65) and OSF (β = 0.38), stress on RAU (β = 0.29), OLP (β = 0.72), OLK (β = 0.38) and OSF (β = 0.60), and anxiety on OLP (β = 0.33), OLK (β = 0.49) and OSF (β = 0.51).

Conclusions: Psychological problems like depression, stress, and anxiety were found to be prevalent in OMDs patients and adversely affected their OHRQoL. The results support the biopsychosocial medical model in the treatment of OMDs patients.

Clinical significance: The present study reinforced the crucial roles of psychological factors in impacting OMDs patients' OHRQoL. Therefore, it is necessary to monitor patients' psychological status and OHRQoL using questionnaires like DASS-21 and OHIP-5. Followed by psychological interventions, the treatment is expected to be enhanced.

Keywords: DASS-21; OHIP-5; Oral health-related quality of life; Oral mucosal; Psychometrics.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The boxplot showed the median and IQR of OHIP-5 scores of four OMDs patient groups. RAU: recurrent aphthous ulcers; OLP: oral lichen planus; OLK: oral leukoplakia; OSF: oral submucous fibrosis.
Fig. 2
Fig. 2
The presence (in percentage) of the three psychological problems in four OMDs patient groups. RAU: recurrent aphthous ulcers; OLP: oral lichen planus; OLK: oral leukoplakia; OSF: oral submucous fibrosis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Petersen P.E. The world oral health report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO global oral health programme. Community Dent. Oral Epidemiol. 2003;31(Suppl 1):3–23. doi: 10.1046/j..2003.com122.x. - DOI - PubMed
    1. Al-Omiri M.K., Karasneh J., Alhijawi M.M., Zwiri A.M., Scully C., Lynch E. Recurrent aphthous stomatitis (RAS): a preliminary within-subject study of quality of life, oral health impacts and personality profiles. J. Oral Pathol. Med. 2015;44(4):278–283. doi: 10.1111/jop.12232. - DOI - PubMed
    1. Specialized Committee on Oral Mucosal Diseases of the Chinese Stomatological Association(CMA) Chinese Stomatological Association of Chinese and Western Medicine Combined Specialized Committee. Guidelines for the diagnosis and treatment of oral lichen planus (revised edition) J Chinese Journal of Stomatology. 2022;57(2):115–121. doi: 10.3760/cma.j.cn112144-20211115-00505. - DOI
    1. Wu X.Z.Z.H., Chen Q.M. Standardized clinical management of oral leukoplakia. J Chinese Journal of Stomatology. 2022;57(8):884–889. doi: 10.3760/cma.j.cn112144-20220606-00304. - DOI - PubMed
    1. Arakeri G., Patil S.G., Aljabab A.S., Lin K.C., Merkx M.A.W., Gao S., Brennan P.A. Oral submucous fibrosis: an update on pathophysiology of malignant transformation. J. Oral Pathol. Med. 2017;46(6):413–417. doi: 10.1111/jop.12582. - DOI - PubMed

LinkOut - more resources