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. 2024 Oct 11;14(4):e12449.
doi: 10.1002/pul2.12449. eCollection 2024 Oct.

Ventricular interdependent phenotype of mixed Cpc-pulmonary hypertension and HFpEF with normal left atrium: Impact on CPET metrics and clinical outcomes

Giovanna Zampierollo-Jaramillo  1 , Anas Abed  1 , Ahmed El Shaer  1 , Mariana Garcia-Arango  1 , Yimin Chen  2 , Babak Tehrani  2 , Wanxin Tu  3 , Abdul Wahab Arif  1 , Shannon Heffernan  1 , Amir Esmaeeli  2 , Aditya Sahai  2 , James Runo  4 , Aurangzeb Baber  2 , Sofia C Masri  5 , Farhan Raza  2
Affiliations

Ventricular interdependent phenotype of mixed Cpc-pulmonary hypertension and HFpEF with normal left atrium: Impact on CPET metrics and clinical outcomes

Giovanna Zampierollo-Jaramillo et al. Pulm Circ. .

Abstract

Among 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV.

Keywords: Cpc‐PH; HFpEF; invasive exercise hemodynamics; pericardial restraint; ventricular interdependence.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
CpcPH HFpEF participants with abnormal (traditional phenotype) and normal left atrium (ventricular interdependent phenotype). *Cardiac MRI‐based: n = 14 in abnormal LA group (blue), n = 6 in normal LA group (green). CpcPH, combined pre and post capillary pulmonary hypertension; E/E’, ratio of mitral inflow to mitral tissue doppler early diastolic velocities; HFpEF, heart failure with preserved ejection fraction; LAVI, left atrial volume index; LV, left ventricle; LV‐TMP, left ventricular transmural pressure (PAWP‐RA); MRI, magnetic resonance imaging; PAWP, pulmonary artery wedge pressure; RA, right atrial pressure; RV, right ventricle.
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