Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 9:18:2851-2863.
doi: 10.2147/OPTH.S469150. eCollection 2024.

Relationship of Corneal Biomechanics Measured by Corvis ST and Optic Nerve Head Parameters in Healthy Saudi Females

Amira Elagamy  1   2 , Hessa Khaled Alnasser  3 , Wafa Saeed Alghamdi  3 , Mohamed Berika  4   5 , Dara Aldisi  6
Affiliations

Relationship of Corneal Biomechanics Measured by Corvis ST and Optic Nerve Head Parameters in Healthy Saudi Females

Amira Elagamy et al. Clin Ophthalmol. .

Abstract

Aim: This study assessed the correlation between corneal biomechanical properties measured with Corvis ST (CST) and retinal nerve fiber layer thickness profile, anterior lamina cribrosa surface depth, and other optic nerve head parameters in healthy Saudi females.

Methods: This study included 62 eyes (only right eyes) of 62 healthy Saudi females aged from 20 to 39 yrs. A complete ophthalmologic assessment was performed for all participants. In addition, corneal biomechanical parameters were measured using CST, and optic nerve head parameters were evaluated using spectral domain optical coherence tomography.

Results: This study demonstrated a significant weak positive correlation between circumpapillary retinal nerve fiber layer (cpRNFL) peak angle and only second applanation (A2) length (mm) (r = 0.293, P = 0.021). Also, this study reported a significant moderate negative association between the C/D ratio and radius (r = -.513, P = 0.015). However, there was no significant correlation between corneal biomechanics and ALCSD in this study.

Conclusion: This study reported a significant positive correlation between cpRNFL peak angle and A2-length. In addition, the current study documented a significant moderate negative association between C/D ratio and radius. However, there was no significant correlation between ALCSD and the corneal biomechanical properties in this study. Further research is needed to verify the impact of corneal biomechanics on optic nerve head parameters and further investigate its role in the pathophysiology of glaucoma.

Keywords: anterior lamina cribrosa surface depth; circumpapillary retinal nerve fiber layer peak angle; corneal biomechanics.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The Circumpapillary Retinal Nerve Fiber Layer (cpRNFL) Peak Angle.
Figure 2
Figure 2
Histogram of the Circumpapillary Retinal Nerve Fiber Layer (cpRNFL) Peak Angles (in Degrees).
Figure 3
Figure 3
The Corneal Biomechanical Parameters Measured using Corvis-ST.
Figure 4
Figure 4
The Linear Fitting Model between A2-Length (mm) and cpRNFL Peak Angle (Degrees).
Figure 5
Figure 5
The Linear Fitting Model between the Peripapillary Retinal Nerve Fiber Layer Thickness (μm) and the Axial Length (mm).
Figure 6
Figure 6
The linear fitting model between the Peripapillary Retinal Nerve Fiber Layer Thickness (μm) and Central Corneal Thickness (μm).
Figure 7
Figure 7
The Linear Fitting Model between Radius (mm) and C/D Ratio.
Figure 8
Figure 8
Anterior Lamina Cribrosa Surface Depth (ALCSD) Measured by Spectral Domain OCT.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Chong J, Dupps WJ. Corneal biomechanics: Measurement and structural correlations. Exp. Eye Res. 2021;205:108508. doi:10.1016/j.exer.2021.108508 - DOI - PMC - PubMed
    1. Pillunat KR, Hermann C, Spoerl E, et al. Analyzing biomechanical parameters of the cornea with glaucoma severity in open-angle glaucoma. Graefes Arch Clin Exp Ophthal. 2016;254(7):1345–1351. doi:10.1007/s00417-016-3365-3 - DOI - PubMed
    1. Mansouri K, Leite MT, Weinreb RN, et al. Association between corneal biomechanical properties and glaucoma severity. Am J Ophthalmol. 2012;153(3):419–427. doi:10.1016/j.ajo.2011.08.022 - DOI - PMC - PubMed
    1. Matsuura M, Hirasawa K, Murata H, et al. The usefulness of CorvisST Tonometry and the Ocular Response Analyzer to assess the progression of glaucoma. Sci Rep. 2017;7(1):40798. doi:10.1038/srep40798 - DOI - PMC - PubMed
    1. Yamashita T, Asaoka R, Kii Y, et al. Structural parameters associated with location of peaks of peripapillary retinal nerve fiber layer thickness in young healthy eyes. PLoS One. 2017;12(5):e0177247. doi:10.1371/journal.pone.0177247 - DOI - PMC - PubMed

LinkOut - more resources