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. 2024 Oct 9:17:821-827.
doi: 10.2147/OTT.S464860. eCollection 2024.

Pregnancy and Breast Cancer: A Challenge for the Multidisciplinary Team. A Single Center Experience and Narrative Review

Fiorella Ruatta  1 , Nerina Denaro  1 , Paola Vanella  2 , Gianluca Tomasello  1 , Ernesto Principe  3 , Grazia Sciancalepore  4 , Carmen Giusy Rea  1 , Ornella Garrone  1
Affiliations

Pregnancy and Breast Cancer: A Challenge for the Multidisciplinary Team. A Single Center Experience and Narrative Review

Fiorella Ruatta et al. Onco Targets Ther. .

Abstract

Purpose: The diagnosis of breast cancer during pregnancy is a rare event, but it is more frequent in our daily clinical practice due to the progressing aging of pregnant women. The management of a woman affected by pregnancy-associated breast cancer (PABC) remains a challenge for the clinician as it is related to ethical and psychological decisions.

Patients and methods: Here, we retrospectively described 10 cases of PABC in women treated at our Institution. All cases were discussed in the multidisciplinary team. We reviewed available literature data on the topic.

Results: Nine out 10 patients were diagnosed with localized breast cancer. The remaining patients were presented with metastatic de novo disease. Median age was 37.5 years (range 26-42). Seven patients presented with grade 3 tumor and 9 patients had Ki-67 value higher than 30%. All but 2 patients received neoadjuvant chemotherapy consisting of sequential anthracyclines and cyclophosphamide followed by weekly paclitaxel during pregnancy. No safety concerns or complications during delivery for both the mothers and the babies were reported.

Conclusion: Breast cancer during pregnancy is a challenging clinical situation and all the decisions need to consider both the patients and the fetus safety. Data from our series and from literature confirm the safety of standard chemotherapy approach starting from the second trimester of gestation. More research and effort are needed to offer these patients excellent outcomes and it is mandatory that cases should be closely followed up by a multidisciplinary team.

Keywords: breast cancer; chemotherapy; multidisciplinarity; pregnancy.

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Conflict of interest statement

Dr Ornella Garrone reports personal fees from MSD, Pfizer, Eisai, Gilead, Lilly, Novartis; travel expenses from Ipsen and Novartis, outside the submitted work. The authors report no other conflicts of interest in this work.

References

    1. Siegel RL, Miller K, Jemal A. Cancer Statistics CA. Cancer J Clin. 2019;69:7–34. doi:10.3322/caac.21551 - DOI - PubMed
    1. Dalmartello M, Negri E, La Vecchia C, et al. Frequency of Pregnancy-Associated Cancer: a Systematic Review of Population-Based Studies. Cancers. 2020;12:1356. doi:10.3390/cancers12061356 - DOI - PMC - PubMed
    1. Alfasi A, Ben-Aharon II. Breast Cancer during Pregnancy—Current Paradigms, Paths to Explore. Cancers. 2019;11(11):1669. doi:10.3390/cancers11111669 - DOI - PMC - PubMed
    1. Poggio F, Tagliamento M, Pirrone C, et al. Update on the Management of Breast Cancer during Pregnancy. Cancers. 2020. doi:10.3390/cancers11111669 - DOI - PMC - PubMed
    1. Shachar SS, Gallagher K, McGuire K, et al. Multidisciplinary Management of Breast Cancer during pregnancy. oncologist. 2017;22(3):324–334. doi:10.1634/theoncologist.2016-0208 - DOI - PMC - PubMed