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Review
. 1979 Dec 14;28(1-3):93-105.
doi: 10.1007/BF00223361.

Fatty acid alpha-hydroxylation and its relation to myelination

Y Kishimoto, H Akanuma, I Singh
Review

Fatty acid alpha-hydroxylation and its relation to myelination

Y Kishimoto et al. Mol Cell Biochem. .

Abstract

alpha-Hydroxylation is an enzymatic reaction by which long-chain fatty acids are converted to their alpha-hydroxy derivatives. This reaction, in animals, can be detected only in developing brain and is the rate-determining step in the synthesis of hydroxycerebroside, which is an indispensable and abundant myelin lipid. In addition to a particulate fraction from brain, two cytoplasmic factors, one heat-stable and the other heat-labile, are required for alpha-hydroxylation. During the past eight years we have been investigating alpha-hydroxylation. Our progress is summarized and discussed here.

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