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Review
. 2024 Oct 14;41(11):271.
doi: 10.1007/s12032-024-02497-0.

The role of kinesin superfamily proteins in hepatocellular carcinoma

Zahraa Sabah Ghnim  1 , Morug Salih Mahdi  2 , Suhas Ballal  3 , Mamata Chahar  4 , Rajni Verma  5 , Ali M Ali Al-Nuaimi  6 , M Ravi Kumar  7 , Rouaida Kadhim A Al-Hussein  8 , Mohaned Adil  9 , Mahmood Jasem Jawad  10
Affiliations
Review

The role of kinesin superfamily proteins in hepatocellular carcinoma

Zahraa Sabah Ghnim et al. Med Oncol. .

Abstract

The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challenge due to its limited therapeutic options. Researchers are currently focused on the complex molecular landscape that governs the initiation and progression of HCC in order to identify new avenues for diagnosis, prognosis, and treatment. In the context of HCC, the Kinesin Superfamily Proteins (KIFs) have become critical regulators of cellular processes, prompting a growing interest in their function among the diverse array of molecular actors implicated in cancer. The KIFs, a family of microtubule-based molecular motors, are renowned for their essential roles in the dynamics of mitotic spindles and intracellular transport. Beyond their well-established functions in normal cellular physiology, emerging evidence indicates that dysregulation of KIFs significantly contributes to the pathogenesis of HCC. Novel therapeutic targets and diagnostic markers are revealed through the unique opportunity to comprehend the complex interplay between KIFs and the molecular events that drive HCC.

Keywords: Hepatocellular carcinoma; Kinesin superfamily; Kinesin superfamily proteins; Metastasis.

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