Disclosure All authors disclosed no financial relationships relevant to the content of this work. Commentary Obscure GI bleeding can be one of the most challenging GI conditions, particularly secondary to Dieulefoy lesions, which are large submucosal arteries that lie close to the exposed mucosal surface and bleed intermittently. Dieulefoy lesions are typically located in the gastric fundus but have been reported throughout the GI tract. The offending exposed artery typically has a small (about 3 mm) diameter, so it is often missed on examination. However, the authors identified a large 2-cm mucosal abnormality that on first glance could have been an aberrant fold. Careful endoscopic examination and high suspicion are key for identifying Dieulefoy lesions. Monica Saumoy, MD, MS, Center for Digestive Health, Penn Medicine Princeton Health, Philadelphia, Pennsylvania, USA Amy Tyberg, MD, FASGE, FACG, Associate Editor for Focal Points