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. 2024 Dec;17(12):e202400305.
doi: 10.1002/jbio.202400305. Epub 2024 Oct 14.

Effect of Photobiomodulation on an Experimental Model of Lower Limb Ischemia

Silvana Torres Perez  1   2 , Lucas Andreo  1 , José Antonio Silva Junior  1   3 , Sandra Kalil Bussadori  1   4 , Anna Carolina Ratto Tempestini Horliana  1 , Raquel Agnelli Mesquita-Ferrari  1   4 , Kristianne Porta Santos Fernandes  1
Affiliations

Effect of Photobiomodulation on an Experimental Model of Lower Limb Ischemia

Silvana Torres Perez et al. J Biophotonics. 2024 Dec.

Abstract

Photobiomodulation (PBM) has been shown to be promising for the promotion of angiogenesis. The present study investigated the effects of PBM on vascularization in an animal model of peripheral artery disease. Wistar rats were divided into three groups. The control group received no procedures. The ischemia group was submitted to ligation of the femoral artery of the hindleg. The ischemia + PBM group was submitted to ligation of the femoral artery followed by PBM (660 and 808 nm, 100 mW, 4 J) over the site. Animals with ischemia treated with PBM exhibited comparable results to the control group with regards to the diameter of the α-SMA+ vessels, cross-sectional area of muscle fibers, percentage of collagen and serum concentration of IL-17A, as well as similarities in terms of vertical mobility, temperature of the hindleg, number of acts of grooming, and percentage of movement, indicating a condition like that of limbs unaffected by ischemia.

Keywords: Photobiomodulation; angiogenesis; arteriogenesis; atherosclerosis; limb ischemia; low‐level laser therapy.

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