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. 2024 Oct 14;24(1):558.
doi: 10.1186/s12872-024-04212-3.

Magnitude of cardiac abnormality and its associated factors among hyperthyroidism patients on follow-up at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Bayu Hailemariam Mersha  1 , Senbeta Guteta Abdissa  2 , Theodros Aberra Alemneh  3 , Natnael Kebede  4 , Yawkal Tsega  5 , Shambel Nigussie  6 , Fekade Demeke Bayou  7
Affiliations

Magnitude of cardiac abnormality and its associated factors among hyperthyroidism patients on follow-up at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Bayu Hailemariam Mersha et al. BMC Cardiovasc Disord. .

Abstract

Background: Thyroid hormones have an effect on every organ system, in particular, the heart responds to minimal changes in serum thyroid hormone level. Thyroid hormone causes a lot of changes in the cardiovascular system, such as increased heart rate, contractility, systolic hypertension, changes in peripheral vascular resistance, atrial fibrillation (AF), and hypercoagulability from the direct effect of thyroid hormone on cardiac myocyte and /or due to increased metabolic state. However, the magnitude of such heart abnormalities and its associated factors were not well studied in Ethiopia.

Objective: To determine the magnitude of cardiac abnormality and its associated factors among hyperthyroidism patients on follow-up at Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia, 2022.

Methods: An institution-based cross-sectional study was carried out among 318 hyperthyroid patients who were on follow-up at the endocrine clinic of TASH, Addis Ababa, Ethiopia from June to October 2022. The data were collected using a pretested structured interviewer administered questionnaire. The data were entered into the computer using EpiData version 3.1 and analyzed using SPSS version 25 software. Bivariable and multivariable logistic regression models were fitted to determine the association between the independent and dependent variables. Adjusted odds ratio with its 95% confidence interval and p-value < 0.05 were used to declare the presence and strength of statistically significant associations.

Result: In this study a total of 318 hyperthyroid patients were participated, most (90.9%) of them were females. The overall prevalence of heart failure among hyperthyroid patients was 17.0% (95% CI = 13.0, 21.6). More than half (52.7%) and one third (33.2%) of the participants showed abnormal electrocardiographic and echocardiographic findings respectively. Marital status (not married) [AOR = 2.37, 95% CI (1.03, 5.44)], pattern of hyperthyroidism [AOR = 13.09, 95% CI (4.70, 36.41)], being Asthmatic [AOR = 7.63, 95% CI (1.55, 37.52)], type of medication [AOR = 3.49, 95% CI (1.11, 11.02)] and duration of treatment [AOR = 4.95, 95% CI (2.05,11.99)] were significantly associated with cardiac abnormality.

Conclusion: A significant portion of hyperthyroid patients overburdened by cardiac abnormalities. Being unmarried, overt hyperthyroid, Asthmatic, long stay on treatment and type of treatment were significantly associated with cardiac abnormality. Hence, attention should be given for cardiac abnormalities while treating hyperthyroid patients.

Keywords: Cardiac abnormality; Ethiopia; Hyperthyroidism; Tikur Anbessa Specialized Hospital.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Thyrocardiac abnormalities among hyperthyroidism patients on follow up at TASH, Addis Ababa, Ethiopia, 2022
See this image and copyright information in PMC

References

    1. Fadeyev VV. Review of American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Clin Experimental Thyroidol. 2017;13(3):45–56.
    1. Albakri A. Thyrotoxic heart failure: a review of clinical status and meta-analysis of electrocardiogram diagnosis and medical clinical management methods. Integr Mol Med. 2018;5:1–11.
    1. Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1). - PubMed
    1. Fadel BM, Ringel MD, Lindsay J, Wartofsky L, Burman HD, Fadel BM. Hyperthyroid Heart Disease. 23.; 2000. - PMC - PubMed
    1. Wyne KL, Nair L, Schneiderman CP, Pinsky B, Antunez Flores O, Guo D, et al. Hypothyroidism Prevalence in the United States: a retrospective study combining National Health and Nutrition Examination Survey and Claims Data, 2009–2019. J Endocr Soc. 2023;7(1):bvac172. - PMC - PubMed

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