Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 30:11:1442274.
doi: 10.3389/fnut.2024.1442274. eCollection 2024.

Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999-2018

Linying Zhu  1 , Xiaoyi Ruan  2 , Jianqi Wang  2 , Yongxing Yan  1 , Chunyuan Tang  3 , Yuanwen Xu  3
Affiliations

Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999-2018

Linying Zhu et al. Front Nutr. .

Abstract

Background: Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) is an emerging composite assessment tool for dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with CKD prevalence in MetS in this national cross-sectional analysis.

Methods: This was a national cross-sectional analysis. Eligible MetS participants ≥20 years of age from NHANES 1999-2018 were included. OBS was assessed according to previous well-validated methods and consisted of 16 dietary components and 4 lifestyle components. MetS was diagnosed by NCEP-ATP III criteria, while CKD was diagnosed by KDIGO 2021 Clinical Practice Guideline. Multivariate logistic regression models were used to explore the association of OBS with CKD in MetS in this national cross-sectional analysis.

Results: A total of 8,095 MetS participants were included, with a CKD prevalence of 24.8%. In fully adjusted models, each score increases in OBS, dietary OBS, and lifestyle OBS was associated with a 2, 1.7, and 7.3% reduction in the prevalence of CKD, respectively. Higher OBS, dietary OBS, and lifestyle OBS were all associated with significantly lower odds of CKD (p for trend all <0.05). Restricted cubic spline analysis showed that these associations all exhibited inverse dose-response. Interaction analyses indicated that cardiovascular disease (CVD) status significantly influenced the impact of OBS and dietary OBS, and these associations were only present in CVD-free subjects. Defining MetS using the IDF criteria did not significantly change the results.

Conclusion: OBS was inversely associated with the prevalence of CKD in MetS, especially in CVD-free settings. These findings emphasize that adherence to an antioxidant diet and lifestyle contributes to the early prevention of CKD in the MetS population and necessitates attention to CVD interactions. Future prospective cohort studies are needed to confirm these results.

Keywords: NHANES; chronic kidney disease; metabolic syndrome; oxidative balance score; oxidative stress.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study population selection, NHANES 1999–2018.
Figure 2
Figure 2
RCS modeling of the association of OBS, dietary OBS, and lifestyle OBS with CKD in the MetS population. (A) OBS; (B) dietary OBS; (C) lifestyle OBS.
Figure 3
Figure 3
Stratified analysis based on inclusion of covariates. (A) OBS; (B) dietary OBS; (C) lifestyle OBS.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. (2009) 2:231–7. doi: 10.1242/dmm.001180, PMID: - DOI - PMC - PubMed
    1. Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. (2018) 20:12. doi: 10.1007/s11906-018-0812-z, PMID: - DOI - PMC - PubMed
    1. Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, et al. . Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci. (2022) 23:786. doi: 10.3390/ijms23020786, PMID: - DOI - PMC - PubMed
    1. Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin N Am. (2014) 43:1–23. doi: 10.1016/j.ecl.2013.09.009 - DOI - PubMed
    1. Abraham NG, Brunner EJ, Eriksson JW, Robertson RP. Metabolic syndrome. Ann N Y Acad Sci. (2007) 1113:256–75. doi: 10.1196/annals.1391.015 - DOI - PubMed

LinkOut - more resources