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. 2024 Sep 30:15:1416326.
doi: 10.3389/fendo.2024.1416326. eCollection 2024.

Changes in serum uteroglobin level in type 2 diabetes mellitus patients

Joung Youl Lim  1 , Sang-Hyeon Ju  2 , Ji Min Kim  3   4 , Hyon-Seung Yi  1   4 , Ju Hee Lee  1   4 , Hyun Jin Kim  1   4 , Bon Jeong Ku  1   4 , Kyong Hye Joung  3   4
Affiliations

Changes in serum uteroglobin level in type 2 diabetes mellitus patients

Joung Youl Lim et al. Front Endocrinol (Lausanne). .

Abstract

Background: Uteroglobin is a multifunctional protein with anti-inflammatory properties. Studies have revealed the importance of inflammation in type 2 diabetes mellitus (T2D) pathogenesis. Here, we investigated the relationship between uteroglobin and T2D.

Methods: We performed diagnostic tests for diabetes in subjects who had not been diagnosed with or treated for T2D. We established three groups, containing those with normal glucose tolerance (NGT), prediabetes and T2D, consisting of 80 people each, and compared their uteroglobin levels. In addition, 28 patients newly diagnosed with T2D were treated with metformin for 12 weeks, and 63 patients newly diagnosed with dyslipidaemia during the treatment for T2D were treated with statin for 12 weeks.

Results: This study showed that uteroglobin levels were significantly lower in prediabetes and T2D groups than in the NGT group. Uteroglobin levels were not significantly correlated with other metabolic parameters, except BMI, HOMA-β and eGFR. In the group treated with metformin or statin, uteroglobin levels increased after treatment compared to before treatment.

Conclusions: Uteroglobin is a sensitive factor that was decreased even in prediabetes and increased upon treatment with drugs with anti-inflammatory effects. Uteroglobin is a potential early biomarker that reflects a chronic inflammatory condition in T2D.

Keywords: SCGB1A1; dyslipidaemia; metformin; prediabetes; statin; type 2 diabetes mellitus; uteroglobin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Serum uteroglobin levels among the NGT, prediabetes and T2D groups in the first banked set. Lines indicate mean and SD. NGT, normal glucose tolerance; T2D, type 2 diabetes mellitus; ns, not significant. p-values were calculated by one-way ANOVA. Differences at p < 0.05 determined by Bonferroni’s significant difference post hoc test are expressed as an asterisk (*).
Figure 2
Figure 2
Changes in serum uteroglobin level after 12 weeks of metformin or statin in type 2 diabetes mellitus patients. Boxes and lines indicate mean and SD. Differences at p < 0.05 determined by paired t test are expressed as an asterisk (*).
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