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. 2024 Oct 15;134(20):e181632.
doi: 10.1172/JCI181632.

Timing of antiretroviral therapy initiation affects intact HIV reservoirs following analytical treatment interruption

Maegan R Manning  1 , Jana Blazkova  1 , Jesse S Justement  1 , Victoria Shi  1 , Brooke D Kennedy  1 , M Ali Rai  1 , Catherine A Seamon  2 , Kathleen Gittens  2 , Michael C Sneller  1 , Susan Moir  1 , Tae-Wook Chun  1
Affiliations

Timing of antiretroviral therapy initiation affects intact HIV reservoirs following analytical treatment interruption

Maegan R Manning et al. J Clin Invest. .
No abstract available

Keywords: AIDS/HIV; Drug therapy.

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Conflict of interest statement

Conflict of interest: The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1. Immunologic and virologic parameters.
Intact and defective HIV proviral DNA (A), correlations (Spearman’s method) between IPD fold change (post-ATI1/pre-ATI) and pre-ATI IPD (B) or plasma viremia during ATI (C), pre-ATI and post-ATI1 residual plasma viremia (D), pre-ATI and post-ATI1 levels of PD-L1 and perforin (E), frequency of MAIT cells (F), polyfunctional HIV-specific T cell response (G), and percentage of CD56dimCD16+CD57+ NK cells (H). Open symbols indicate values under the limit of detection, and black bars indicate the geometric mean or median. P values were determined using Wilcoxon’s matched-pairs signed rank test (A, D, and E) and adjusted using the Holm-Bonferroni method (A) and the Mann-Whitney U test (F–H).
See this image and copyright information in PMC

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