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Review
. 2024 Dec;14(12):1921-1928.
doi: 10.1002/alr.23469. Epub 2024 Oct 15.

Research progress in OX40/OX40L in allergic diseases

Rongrong Song  1 , Huanlei Zhang  1 , Zhuoping Liang  1
Affiliations
Review

Research progress in OX40/OX40L in allergic diseases

Rongrong Song et al. Int Forum Allergy Rhinol. 2024 Dec.

Abstract

OX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T-cell-mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.

Keywords: OX40; OX40L; allergic rhinitis; asthma; atopic dermatitis.

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