Evaluation and treatment of rhinosinusitis with primary antibody deficiency in children: Evidence-based review with recommendations

Chadi A Makary¹, Antoine Azar², David Gudis³, Anna Crawford⁴, Paavali Hannikainen⁵, Jean Kim⁶, Stephanie Joe⁷, Adam J Kimple⁸, Kent Lam⁹, Jivianne T Lee¹⁰, Amber U Luong¹¹, Sonya Marcus¹², Erica McArdle¹, Warren Mullings¹³, Brian P Peppers¹⁴, Callum Lewandrowski¹⁴, Sandra Y Lin¹⁵, Hassan H Ramadan¹, Austin S Rose⁸, Lindsey Ryan¹⁶, Elina Toskala¹⁷, Fuad M Baroody¹⁸

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, West Virginia, USA.
² Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York, USA.
⁴ Health Sciences Library, Morgantown, West Virginia, USA.
⁵ Department of Otolaryngology-Head and Neck Surgery, Northwestern University, Chicago, Illinois, USA.
⁶ Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁷ Department of Otolaryngology-Head and Neck Surgery, University of Illinois, Chicago, Illinois, USA.
⁸ Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
⁹ Department of Otolaryngology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
¹⁰ Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Otorhinolaryngology, McGovern Medical School of the University of Texas Health Science Center, Houston, Texas, USA.
¹² Division of Otolaryngology-Head and Neck Surgery, Stony Brook University, Stony Brook, New York, USA.
¹³ Ear Nose and Throat Department, Kingston Public Hospital, Kingston, Jamaica.
¹⁴ Division of Adult and Pediatric Allergy and Immunology, Department of Pediatrics, West Virginia University, Morgantown, West Virginia, USA.
¹⁵ Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
¹⁶ Department of Otolaryngology-Head and Neck Surgery, University of South Florida, Tampa, Florida, USA.
¹⁷ Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
¹⁸ Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine, The Comer Children's Hospital, Chicago, Illinois, USA.

PMID: 39404739
DOI: 10.1002/alr.23468

Evaluation and treatment of rhinosinusitis with primary antibody deficiency in children: Evidence-based review with recommendations

Chadi A Makary et al. Int Forum Allergy Rhinol. 2024 Nov.

. 2024 Nov;14(11):1776-1801.

doi: 10.1002/alr.23468. Epub 2024 Oct 15.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown, West Virginia, USA.
² Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Otolaryngology-Head and Neck Surgery, Columbia University Irving Medical Center, New York, New York, USA.
⁴ Health Sciences Library, Morgantown, West Virginia, USA.
⁵ Department of Otolaryngology-Head and Neck Surgery, Northwestern University, Chicago, Illinois, USA.
⁶ Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁷ Department of Otolaryngology-Head and Neck Surgery, University of Illinois, Chicago, Illinois, USA.
⁸ Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
⁹ Department of Otolaryngology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
¹⁰ Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
¹¹ Department of Otorhinolaryngology, McGovern Medical School of the University of Texas Health Science Center, Houston, Texas, USA.
¹² Division of Otolaryngology-Head and Neck Surgery, Stony Brook University, Stony Brook, New York, USA.
¹³ Ear Nose and Throat Department, Kingston Public Hospital, Kingston, Jamaica.
¹⁴ Division of Adult and Pediatric Allergy and Immunology, Department of Pediatrics, West Virginia University, Morgantown, West Virginia, USA.
¹⁵ Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
¹⁶ Department of Otolaryngology-Head and Neck Surgery, University of South Florida, Tampa, Florida, USA.
¹⁷ Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
¹⁸ Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine, The Comer Children's Hospital, Chicago, Illinois, USA.

PMID: 39404739
DOI: 10.1002/alr.23468

Abstract

Background: There is clear evidence that prevalence of primary antibody deficiency (PAD) is higher in children with chronic rhinosinusitis (CRS) than in the general population. The purpose of this multi-institutional and multidisciplinary evidence-based review with recommendations (EBRR) is to thoroughly review the literature on rhinosinusitis with PAD, summarize the existing evidence, and provide recommendations on the evaluation and management of rhinosinusitis in children with PAD.

Methods: The PubMed, Embase, and Cochrane databases were systematically reviewed from inception through December 2023. Studies on the evaluation and management of rhinosinusitis in PAD patients were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on the evaluation and management principles for PAD were generated.

Results: A total of 50 studies were included in this evidence-based review. These studies were evaluated on the incidence of PAD in rhinosinusitis patients, the incidence of rhinosinusitis in PAD patients, and on the different treatment modalities used and their outcome. The aggregate quality of evidence varied across the reviewed domains.

Conclusion: Based on the currently available evidence, the incidence of PAD in children with recalcitrant CRS can be significantly elevated. Despite the presence of multiple studies addressing rhinosinusitis and PAD, the level of evidence supporting different treatment options continues to be lacking. Optimal management requires a multidisciplinary approach through collaboration with clinical immunology. There is need for higher level studies that compare different treatments in children with PAD and rhinosinusitis.

Keywords: antibody deficiency; chronic rhinosinusitis; evaluation; immunodeficiency disorders; recommendations; recurrent acute rhinosinusitis; treatment.

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References

REFERENCES

1. Orlandi RR, Kingdom TT, Smith TL, et al. International consensus statement on allergy and rhinology: rhinosinusitis 2021. Int Forum Allergy Rhinol. 2021;11(3):213‐739. doi:10.1002/alr.22741
1. Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58(S29):1‐464. doi:10.4193/Rhin20.600
1. Ramadan HH, Chaiban R, Makary C. Pediatric rhinosinusitis. Pediatr Clin North Am. 2022;69(2):275‐286. doi:10.1016/j.pcl.2022.01.002
1. Bhattacharyya N, Jones DT, Hill M, Shapiro NL. The diagnostic accuracy of computed tomography in pediatric chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg. 2004;130(9):1029‐1032. doi:10.1001/archotol.130.9.1029
1. Bonilla FA, Khan DA, Ballas ZK, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol. 2015;136(5):1186‐1205.e1‐78. doi:10.1016/j.jaci.2015.04.049

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Evaluation and treatment of rhinosinusitis with primary antibody deficiency in children: Evidence-based review with recommendations

Affiliations

Evaluation and treatment of rhinosinusitis with primary antibody deficiency in children: Evidence-based review with recommendations

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical