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Comparative Study
. 2025 Mar;282(3):1231-1236.
doi: 10.1007/s00405-024-09025-w. Epub 2024 Oct 15.

Comparative analysis of classic and delayed Ménière's disease: clinical characteristics and endolymphatic hydrops manifestations in an Asian cohort

Suming Shi #  1   2 , Xu Liu #  1   2 , Wenquan Li #  3 , Dan Wang  1   2 , Wuqing Wang  4   5
Affiliations
Comparative Study

Comparative analysis of classic and delayed Ménière's disease: clinical characteristics and endolymphatic hydrops manifestations in an Asian cohort

Suming Shi et al. Eur Arch Otorhinolaryngol. 2025 Mar.

Abstract

Objective: To investigate the clinical characteristics and endolymphatic hydrops (ELH) Manifestations in patients with delayed Ménière's disease (DMD) compared to classic Ménière's disease (CMD).

Methods: A prospective cohort study was conducted involving 523 patients diagnosed with MD. Clinical data, inner ear function, and ELH characteristics were analyzed and compared between CMD and DMD groups. Assessments included audiometry, VEMP, and MRI.

Results: DMD prevalence was 6.1%. Bilateral MD was significantly more common in DMD (34.4% vs. 14.5%, P = 0.003). DMD patients had more severe hearing loss in the first involved ear and more deteriorated VEMP in the contralateral ear (P < 0.05). ELH was present in 100% of affected ears, with a higher contralateral ELH proportion in DMD (34.4% vs. 15.0%, P = 0.005).

Conclusions: DMD patients exhibit a higher prevalence of bilateral MD, more severe hearing loss, and greater contralateral ELH compared to CMD patients. Both subtypes share similar ELH characteristics, suggesting common underlying mechanisms.

Keywords: Bilateral ménière’s disease; Classic ménière’s disease; Clinical characteristics; Delayed ménière’s disease; Endolymphatic hydrops.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no other funding, financial relationships, or conflicts of interest to disclose.

References

    1. Lopez-Escamez JA et al (2015) Diagnostic criteria for Menière’s disease. J Vestib Res 25(1):1–7 - DOI - PubMed
    1. Kamei T (2004) Delayed endolymphatic hydrops as a clinical entity. Int Tinnitus J 10(2):137–143 - PubMed
    1. LeLiever WC, Barber HO (1980) Delayed endolymphatic hydrops. J Otolaryngol 9(5):375–380 - PubMed
    1. Harris JP, Aframian D (1994) Role of autoimmunity in contralateral delayed endolymphatic hydrops. Am J Otol 15(6):710–716 - PubMed
    1. Suzuki M et al (2006) Autoantibodies against inner ear proteins in patients with delayed endolymphatic hydrops and unilateral juvenile deafness. Acta Otolaryngol 126(2):117–121 - DOI - PubMed

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