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Review
. 2024 Nov:180:117551.
doi: 10.1016/j.biopha.2024.117551. Epub 2024 Oct 13.

Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms

Lirong Yan  1 , Zhenpeng Wen  2 , Yi Yang  3 , Aoran Liu  1 , Fang Li  1 , Yuzhe Zhang  1 , Chunjiao Yang  4 , Yanke Li  5 , Ye Zhang  6
Affiliations
Free article
Review

Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms

Lirong Yan et al. Biomed Pharmacother. 2024 Nov.
Free article

Abstract

As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. In addition, PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling. Moreover, under different situations, PSAP exhibits distinct metastasis potentials in tumors. However, comprehensive insight into PSAP in cancer progression has been lacking. Here, we provide a framework of the role of PSAP in cancer and its clinical application in cancer patients, providing a novel perspective on the clinical translation of PSAP.

Keywords: Application; Cancer; Extracellular; Hallmarks; PSAP; Therapeutic target.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.