Macrophage Cell Cycle

Louis Dillac¹, Leon El Dika², Rahim Ullah³, Jacek Z Kubiak^{4

5}, Malgorzata Kloc^{6

7

8}

Affiliations

¹ Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
² Laboratoire Huckert's International, Wavre, Belgium.
³ Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
⁴ Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine-National Research Institute (WIM-PIB), Warsaw, Poland.
⁵ Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, Rennes, France.
⁶ Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.
⁷ Houston Methodist Hospital, Department of Surgery, Houston, TX, USA.
⁸ University of Texas, Md Anderson Cancer Center, Department of Genetics, Houston, TX, USA.

PMID: 39406903
DOI: 10.1007/978-3-031-65944-7_4

Review

Macrophage Cell Cycle

Louis Dillac et al. Results Probl Cell Differ. 2024.

. 2024:74:119-134.

doi: 10.1007/978-3-031-65944-7_4.

Authors

Louis Dillac¹, Leon El Dika², Rahim Ullah³, Jacek Z Kubiak^{4

5}, Malgorzata Kloc^{6

7

8}

Affiliations

¹ Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
² Laboratoire Huckert's International, Wavre, Belgium.
³ Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
⁴ Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine-National Research Institute (WIM-PIB), Warsaw, Poland.
⁵ Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, Rennes, France.
⁶ Houston Methodist Research Institute, Transplant Immunology, Houston, TX, USA.
⁷ Houston Methodist Hospital, Department of Surgery, Houston, TX, USA.
⁸ University of Texas, Md Anderson Cancer Center, Department of Genetics, Houston, TX, USA.

PMID: 39406903
DOI: 10.1007/978-3-031-65944-7_4

Abstract

Macrophages are dynamic and plastic immune cells essential for tissue homeostasis and pathogen defense. Their cell cycle regulation is highly influenced by intrinsic and extrinsic signals facilitating rapid responses to infections and tissue damage. Dysregulation of their cell cycle leads to diseases like cancer and HIV. This chapter highlights aspects of the macrophage cell cycle crucial for the development of targeted therapies.

Keywords: Cellular proliferation; Disease progression; Macrophage cell cycle; Molecular regulators; Plasticity.

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Cited by

Dynamic macrophage phenotypes in autoimmune and inflammatory rheumatic diseases.
Cutolo M, Soldano S, Smith V, Gotelli E, Hysa E. Cutolo M, et al. Nat Rev Rheumatol. 2025 Sep;21(9):546-565. doi: 10.1038/s41584-025-01279-w. Epub 2025 Jul 28. Nat Rev Rheumatol. 2025. PMID: 40721670 Review.

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Macrophage Cell Cycle

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Macrophage Cell Cycle

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