Macrophage Cell Cycle
- PMID: 39406903
- DOI: 10.1007/978-3-031-65944-7_4
Macrophage Cell Cycle
Abstract
Macrophages are dynamic and plastic immune cells essential for tissue homeostasis and pathogen defense. Their cell cycle regulation is highly influenced by intrinsic and extrinsic signals facilitating rapid responses to infections and tissue damage. Dysregulation of their cell cycle leads to diseases like cancer and HIV. This chapter highlights aspects of the macrophage cell cycle crucial for the development of targeted therapies.
Keywords: Cellular proliferation; Disease progression; Macrophage cell cycle; Molecular regulators; Plasticity.
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
References
-
- A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, De La Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A (2013) The nuclear receptor LXRα controls the functional specialization of splenic macrophages. Nat Immunol 14(8):831–839. https://doi.org/10.1038/NI.2622 - DOI - PubMed - PMC
-
- Antonucci JM, St Gelais C, Wu L (2017) The dynamic interplay between HIV-1, SAMHD1, and the innate antiviral response. Front Immunol 8:1541. https://doi.org/10.3389/fimmu.2017.01541 - DOI - PubMed - PMC
-
- Aravindaram K, Yang NS (2010) Anti-inflammatory plant natural products for cancer therapy. Planta Med 76(11):1103–1117. https://doi.org/10.1055/s-0030-1249859 - DOI - PubMed
-
- Ashcroft GS (1999) Bidirectional regulation of macrophage function by TGF-beta. Microbes Infect 1(15):1275–1282. https://doi.org/10.1016/S1286-4579(99)00257-9 - DOI - PubMed
-
- Badia R, Pujantell M, Riveira-Muñoz E, Puig T, Torres-Torronteras J, Martí R, Clotet B, Ampudia RM, Vives-Pi M, Esté JA, Ballana E (2016) The G1/S specific cyclin D2 is a regulator of HIV-1 restriction in non-proliferating cells. PLoS Pathog 12(8):e1005829. https://doi.org/10.1371/JOURNAL.PPAT.1005829 - DOI - PubMed - PMC
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources

