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Review
. 2024 Sep 27;13(19):5775.
doi: 10.3390/jcm13195775.

A Review on Asthma and Allergy: Current Understanding on Molecular Perspectives

Gassem Gohal  1 , Sivakumar S Moni  2   3 , Mohammed Ali Bakkari  3   4 , Mohamed Eltaib Elmobark  2
Affiliations
Review

A Review on Asthma and Allergy: Current Understanding on Molecular Perspectives

Gassem Gohal et al. J Clin Med. .

Abstract

Asthma, a complex disease characterized by persistent airway inflammation, remains an urgent global health concern. We explored the critical role of allergic biomarkers and dysregulated immune system in asthma through an extensive literature review in databases such as Web of Science, PubMed, EMBASE, Scopus, and Google Scholar. This review summarizes the growing data on the pivotal role of allergic biomarkers and dysregulated immune system in the development and evolution of asthma. Recent studies have uncovered several biomarkers that elucidate intrinsic allergic mechanisms in individuals with asthma. This article highlights these biomarkers' potential in predicting asthma onset, assessing its intensity, guiding therapeutic interventions, and tracking disease progression. We also explore the innovative therapeutic prospects arising from the convergence of allergy and dysregulated immune system in asthma and emphasize the potential for precision medicine approaches. Understanding allergic biomarkers intertwined with a dysregulated immune system heralds a new era in asthma treatment and points to improved and individualized treatment modalities.

Keywords: allergic biomarkers; asthma; autoimmunity; cytokine network; dysregulated immune system; mechanistic approach.

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Conflict of interest statement

Authors declare that there is no conflict of interest either financial or nonfinancial.

Figures

Figure 1
Figure 1
Immune mechanism in allergic asthma.
See this image and copyright information in PMC

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